Renewable DNA Hairpin-Based Logic Circuits
Renewable DNA Hairpin-Based Logic Circuits
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DOI：
10.1109/tnano.2019.2896189
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发表时间：
2019-01-01
影响因子：
2.4
通讯作者：
Reif, John
中科院分区：
文献类型：
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作者：
Eshra, Abeer;Shah, Shalin;Reif, John
开发具有理想功能的智能分子系统是当前纳米科学领域的一个重要研究课题。已经探索了几种材料来构建有趣的系统，如分子马达、分子行走器和布尔逻辑电路。脱氧核糖核酸（DNA）是应用最广泛的材料之一，因为沃森-克里克碱基配对使其成为多功能底物。DNA纳米科学的一项重大成就是大规模逻辑电路的构建。然而，大多数先前的工作都集中在开发一次性DNA逻辑电路上。这些一次性电路可以执行强大的计算。然而，计算材料，如门链，不能被重用来再次实现相同（或不同）的计算。这种可重用行为对于应用程序（如反馈和顺序逻辑计算）是必不可少的。在本文中，我们提出了一种新的设计策略来构建可再生的DNA逻辑电路。首先，我们提出了一个基于可再生DNA发夹的基序，然后使用该基序实现布尔逻辑门。这种可更新的电路使得整个样品制备变得方便和直接。我们相信，我们的工作将为可再生智能分子系统的发展播下种子。
Developing intelligent molecular systems for the desired functions is a significant current research topic in the field of nanoscience. Several materials have been explored to construct interesting systems, such as molecular motors, molecular walkers, and Boolean logic circuits. Deoxyribonucleic acid (DNA) is one of the most widely used materials as the Watson-Crick base pairing makes it a versatile substrate. A significant achievement in DNA nanoscience has been the construction of large-scale logic circuits. However, most of the prior works have focused on developing the single-use DNA logic circuits. These single-use circuits can perform robust computations. However, the computing material, such as gate strands, cannot be reused to achieve the same (or a different) computation again. Such reusable behavior is essential for applications, such as feedback and sequential logic computation. In this paper, we propose a novel design strategy for building renewable DNA logic circuits. First, we propose a renewable DNA hairpin-based motif and, then, use this motif to implement a Boolean logic gate. Such renewable circuits make the overall sample preparation convenient and straightforward. We believe that our work will serve as a seed for the development of renewable intelligent molecular systems.