Does A Placebo Tablet Affect Psychotherapeutic Treatment Outcome? Results from the Pittsburgh Study of Maintenance Therapies in Recurrent Depression
Does A Placebo Tablet Affect Psychotherapeutic Treatment Outcome? Results from the Pittsburgh Study of Maintenance Therapies in Recurrent Depression
复制标题
安慰剂片剂会影响心理治疗结果吗？
DOI：
--
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
D. Kupfer
中科院分区：
文献类型：
--
作者：
E. Frank;D. Kupfer
由于药物和心理治疗的组合越来越多地用于随机临床试验，一个重要的问题是，双盲安慰剂片剂的心理治疗是否不同于不伴随服药的心理治疗。这项研究报告，对于进入长期维持试验的复发性抑郁症患者，这两种治疗条件在治疗结果（例如，复发、再稳定、损耗），心理生物学参数（例如，恢复中的睡眠生理学）或治疗特异性等级。我们的研究结果表明，无论是安慰剂片剂条件下的心理治疗或更生态有效的心理治疗没有安慰剂片剂可能是适合在长期维持治疗复发性抑郁症的试验。这些结果是否可以推广到急性治疗试验或其他疾病的长期研究仍然是一个悬而未决的问题。
Since combinations of medication and psychotherapy are being increasingly used in randomized clinical trials, an important issue is whether psychotherapy administered with a double-blind placebo tablet is different from psychotherapy unaccompanied by pill-taking. This study reports no significant differences in these two treatment conditions for patients with recurrent depression entered into a long-term maintenance trial with respect to either treatment outcome (e.g., recurrence, restabilization, attrition), psychobiological parameters (e.g., sleep physiology in recovery), or treatment specificity ratings. Our findings suggest that either a psychotherapy with placebo tablet condition or a more ecologically valid psychotherapy without placebo tablet may be suitable in long-term maintenance treatment trials of recurrent depression. Whether these results can be generalized to acute treatment trials or to long-term studies of other disorders remains an open question.