The Origins and Early Days of the Three Rs Concept
The Origins and Early Days of the Three Rs Concept
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DOI：
10.1177/026119290903700306
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发表时间：
2009-07-01
影响因子：
2.7
通讯作者：
Balls, Michael
中科院分区：
文献类型：
--
作者：
Balls, Michael
50年前，罗素和伯奇在《人道实验技术原理》一书中阐述了与动物实验有关的三个r（替代、减少、改进）概念的起源，通过参考一些重要出版物和W.M.S.和克莱尔罗素档案（目前正在诺丁汉大学建立）的信件，回答了一些问题。本书还深入探讨了罗素和伯奇之间的关系、“替代”一词在3r语境中的首次使用，以及本书出版的背景。
Some questions are answered concerning the origins of the Three Rs (Replacement, Reduction, Refinement) concept in relation to animal experimentation, expounded 50 years ago by Russell and Burch in The Principles of Humane Experimental Technique, by reference to some key publications and to correspondence in the W.M.S. and Claire Russell Archive, which is currently being established at the University of Nottingham. Some insight is also given into the relationship between Russell and Burch, the first use of "alternatives" in the Three Rs context, and the background to the publication of the book.