Randomized, double-blind, pilot study of geranylgeranylacetone versus placebo in patients taking low-dose enteric-coated aspirin. Low-dose aspirin-induced small bowel damage
Randomized, double-blind, pilot study of geranylgeranylacetone versus placebo in patients taking low-dose enteric-coated aspirin. Low-dose aspirin-induced small bowel damage
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DOI：
10.3109/00365520903453182
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发表时间：
2010-03-01
影响因子：
1.9
通讯作者：
Graham, David Y.
中科院分区：
文献类型：
--
作者：
Shiotani, Akiko;Haruma, Ken;Graham, David Y.
客观的。低剂量肠溶阿司匹林越来越多地用于预防心血管疾病。本研究的目的是评估香叶基香叶丙酮（GGA）是否可以预防阿司匹林引起的小肠损伤。材料和方法。这是一项针对服用低剂量肠溶阿司匹林的受试者进行的 GGA 与安慰剂的前瞻性、随机、双盲试点研究。招募年轻健康志愿者，每人每天服用 100 毫克肠溶阿司匹林加 GGA（150 毫克/天）或匹配的安慰剂，持续 7 天。在服用阿司匹林之前和之后进行小肠视频胶囊内窥镜检查和胃肠道症状评定量表（GSRS）问卷。结果。对二十名志愿者进行了评估。接受或未接受 GGA 的患者之间任何类别的病变数量均无显着差异。 12 名（60%；95% 置信区间 36%-80%）阿司匹林使用者观察到大面积糜烂或溃疡。粘膜破裂最常见于近端小肠的后半部分。结论。短期服用低剂量肠溶阿司匹林与大多数使用者可见的小肠损伤有关。我们无法证明 GGA 可以预防阿司匹林引起的小肠粘膜损伤。
Objective. Low-dose enteric-coated aspirin is increasingly being used for prevention of cardiovascular disease. The aim of this study was to evaluate whether geranylgeranylacetone (GGA) could prevent aspirin-induced small bowel injury. Material and methods. This was a prospective, randomized, double-blind, pilot study of GGA versus placebo in subjects taking low-dose enteric-coated aspirin. Young healthy volunteers were enrolled and each received 100 mg of enteric-coated aspirin per day plus either GGA (150 mg/day) or matching placebo for 7 days. Video capsule endoscopy of the small bowel and the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire were performed before and after the administration of aspirin. Results. Twenty volunteers were evaluated. There was no significant difference in the number of lesions in any category between those receiving or not receiving GGA. Large erosions or ulcers were observed in 12 (60%; 95% confidence interval 36%- 80%) aspirin users. Mucosal breaks were most frequently found in the latter half of the proximal small bowel. Conclusions. Short-term administration of low-dose enteric-coated aspirin was associated with visible small bowel damage in the majority of users. We could not prove that aspirin-induced small bowel mucosal injury was prevented by GGA.