Autonomic dysfunction in presymptomatic and early symptomatic Huntington's disease
Autonomic dysfunction in presymptomatic and early symptomatic Huntington's disease
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DOI：
10.1111/j.1600-0404.2009.01251.x
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发表时间：
2010-06-01
影响因子：
3.5
通讯作者：
Zaletel, M.
中科院分区：
文献类型：
--
作者：
Kobal, J.;Melik, Z.;Zaletel, M.
虽然在晚期亨廷顿舞蹈病（HD）患者中发现了自主神经功能障碍，但在症状前和症状早期亨廷顿舞蹈病中是否存在自主神经功能障碍尚不清楚。材料与方法：对14名症状前HD突变携带者（PHD）、11名早期症状HD患者（EHD）和25名性别和年龄匹配的对照组进行了不同的心血管自主神经测试。结果-我们发现简单心算测试反应减弱（PHD组和EHD组的相对心率比对照组低10%，EHD组的舒张压比对照组低10.6%,P < 0.05），冷压试验后期反应夸大（PHD组的相对心率比对照组高10%，EHD组的相对心率比对照组高7%，P < 0.05）。其余的心血管自主测试没有显示出患者和对照组之间的显著差异。结论：我们的研究结果表明，即使在PHD和EHD中也存在细微的自主神经功能障碍。
Objectives -Although autonomic dysfunction was found in advanced Huntington's disease (HD) patients it is not clear whether there is autonomic dysfunction in presymptomatic and early symptomatic HD.Material & methods -Different cardiovascular autonomic tests were performed in 14 presymptomatic HD mutation carriers (PHD), 11 early symptomatic HD patients (EHD) and in 25 sex and age matched controls.Results -We found attenuated response to simple mental arithmetic test (relative heart rate in PHD and EHD was 10% lower than in controls; diastolic pressure was 10.6% lower in EHD than in controls; P < 0.05) and exaggerated response to the late phase of cold pressor test (relative heart rate was 10% higher in PHD and 7% higher in EHD than in controls; P < 0.05). The rest of the cardiovascular autonomic tests did not reveal significant differences between patients and controls.Conclusions -Our results suggest that subtle autonomic dysfunction occurs even in PHD and EHD.