Human leukocyte antigen-A24 and -DQA1*0301 in Japanese insulin-dependent diabetes mellitus: independent contributions to susceptibility to the disease and additive contributions to acceleration of beta-cell destruction.
Human leukocyte antigen-A24 and -DQA1*0301 in Japanese insulin-dependent diabetes mellitus: independent contributions to susceptibility to the disease and additive contributions to acceleration of beta-cell destruction.
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日本胰岛素依赖性糖尿病中的人类白细胞抗原 -A24 和 -DQA1*0301：对疾病易感性的独立贡献和对加速 β 细胞破坏的附加贡献。
DOI：
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发表时间：
1999
影响因子：
5.8
通讯作者：
H. Inoko
中科院分区：
文献类型：
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作者：
K. Nakanishi;T. Kobayashi;T. Murase;T. Naruse;Y. Nose;H. Inoko
本研究的目的是在没有确定的危险等位基因HLA-DQA 1 *0301的胰岛素依赖型糖尿病（insulin dependent diabetes mellitus，IDDM）患者中鉴定易感HLA抗原，并分析这些HLA抗原与β细胞破坏程度的关系。对139例日本人胰岛素依赖型糖尿病患者和158例正常人进行了HLA-A、-C、-B、-DR和-DQ抗原分型。100 g口服葡萄糖负荷≤ 0.033 nmol/l的血清C肽免疫反应性（deltaCPR）被认为是β细胞完全破坏。所有14例无HLA-DQA 1 *0301的患者都有HLA-A24，而58例无HLA-DQA 1 *0301的正常对照中只有35例（60.3%）和125例有HLA-DQA 1 *0301的IDDM患者中只有72例（57.6%）有这种抗原（分别为Pc = 0.0256和Pc = 0.0080）。携带HLA-DQA 1 *0301和HLA-A24的IDDM患者的DeltaCPR（0.097 +/- 0.163 nmol/L，平均值+/- SD，n = 65）低于仅携带HLA-DQA 1 *0301的IDDM患者（0.219 ± 0.237 nmol/L，n = 45，P < 0.0001），仅HLA-A24的IDDM患者（0.187 ± 0.198 nmol/L，n = 14，P = 0.0395）。这些结果表明，HLA-DQA 1 *0301和HLA-A24都独立地促进了对IDDM的易感性，并以相加的方式加速了β细胞的破坏。
The aim of this study is to identify insulin-dependent diabetes mellitus (IDDM)-susceptible HLA antigens in IDDM patients who do not have established risk allele, HLA-DQA1*0301, and analyze relationship of these HLA antigens and the degree of beta-cell destruction. In 139 Japanese IDDM patients and 158 normal controls, HLA-A, -C, -B, -DR and -DQ antigens were typed. Serum C-peptide immunoreactivity response (deltaCPR) to a 100-g oral glucose load < or = 0.033 nmol/l was regarded as complete beta-cell destruction. All 14 patients without HLA-DQA1*0301 had HLA-A24, whereas only 35 of 58 (60.3%) normal controls without HLA-DQA1*0301 and only 72 of 125 (57.6%) IDDM patients with HLA-DQA1*0301 had this antigen (Pc = 0.0256 and Pc = 0.0080, respectively). DeltaCPR in IDDM patients with both HLA-DQA1*0301 and HLA-A24 (0.097 +/- 0.163 nmol/L, mean +/- SD, n = 65) were lower than in IDDM patients with HLA-DQA1*0301 only (0.219 +/- 0.237 nmol/L, n = 45, P < 0.0001) and in IDDM patients with HLA-A24 only (0.187 +/- 0.198 nmol/L, n = 14, P = 0.0395). These results indicate that both HLA-DQA1*0301 and HLA-A24 contribute susceptibility to IDDM independently and accelerate beta-cell destruction in an additive manner.