Short frontal lobe connections of the human brain
Short frontal lobe connections of the human brain
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DOI：
10.1016/j.cortex.2011.12.001
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发表时间：
2012-02-01
期刊：
影响因子：
3.6
通讯作者：
Thiebaut de Schotten, Michel
中科院分区：
文献类型：
--
作者：
Catani, Marco;Dell'Acqua, Flavio;Thiebaut de Schotten, Michel
我们对感觉-运动整合的理解的进展表明额叶回路在认知和行为中具有独特的作用。长距离传入连接将高阶感觉信息传递到额叶皮层，额叶皮层反过来以灵活和适应性行为对内部和外部刺激做出反应。长距离连接和额叶已被详细描述在猴子，但很少有人知道短叶内额叶连接介导的本地连接在人类。在这里，我们使用球形去卷积弥散纤维束成像和死后解剖来可视化人脑的短额叶连接。我们确定了三个叶内束连接：i）后布罗卡区与补充运动区（SMA）和前补充运动区（pre-SMA）（即，额“倾斜”束- FAT）; ii）具有前极区的后眶额皮质（即，额眶极束（FOP）; iii）后中央前皮质与前额叶前皮质（即，额上级纵行- FSL小束系统）。此外，在中央、中央前、岛周和额缘沟（FMS）区域发现了更复杂的短U形纤维系统。在一组12名健康右利手的受试者中，发现Broca和内侧额叶区（即FAT）之间的联系以及手旋钮运动区和中央后回（PoCG）之间的联系向左偏侧。这些短额连接的存在，证实了使用死后钝性解剖。这些道在运动学习，语言流畅性，前瞻性行为，情节和工作记忆的功能作用进行了讨论。我们的研究提供了一个一般模型的局部连接的额叶，可作为一个解剖框架的研究偏侧化和未来的临床研究在神经和精神疾病。(C)2011 Elsevier Srl. All rights reserved.
Advances in our understanding of sensory-motor integration suggest a unique role of the frontal lobe circuits in cognition and behaviour. Long-range afferent connections convey higher order sensory information to the frontal cortex, which in turn responds to internal and external stimuli with flexible and adaptive behaviour. Long-range connections from and to frontal lobes have been described in detail in monkeys but little is known about short intralobar frontal connections mediating local connectivity in humans. Here we used spherical deconvolution diffusion tractography and post-mortem dissections to visualize the short frontal lobe connections of the human brain. We identified three intralobar tracts connecting: i) posterior Broca's region with supplementary motor area (SMA) and pre-supplementary motor area (pre-SMA) (i.e., the frontal 'aslant' tract - FAT); ii) posterior orbitofrontal cortex with anterior polar region (i.e., fronto-orbitopolar tract - FOP); iii) posterior pre-central cortex with anterior prefrontal cortex (i.e., the frontal superior longitudinal - FSL faciculus system). In addition more complex systems of short U-shaped fibres were identified in the regions of the central, pre-central, perinsular and fronto-marginal sulcus (FMS). The connections between Broca and medial frontal areas (i.e. FAT) and those between the hand-knob motor region and post-central gyrus (PoCG) were found left lateralized in a group of twelve healthy right-handed subjects. The existence of these short frontal connections was confirmed using post-mortem blunt dissections. The functional role of these tracts in motor learning, verbal fluency, prospective behaviour, episodic and working memory is discussed. Our study provides a general model for the local connectivity of the frontal lobes that could be used as an anatomical framework for studies on lateralization and future clinical research in neurological and psychiatric disorders. (C) 2011 Elsevier Srl. All rights reserved.