Malignancy may adversely influence the quality and behaviour of oocytes
Malignancy may adversely influence the quality and behaviour of oocytes
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DOI：
10.1093/humrep/13.7.1837
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发表时间：
1998-07-01
影响因子：
6.1
通讯作者：
Toth, TL
中科院分区：
文献类型：
--
作者：
Pal, L;Leykin, L;Toth, TL
本文报告了一组8个周期的体外受精(IVF)病例，其中包括5名被诊断为恶性疾病的妇女。这些患者选择推迟最终治疗，以获得保留潜在生育能力的机会。比较这些患者对卵巢刺激的反应和结局，对12例年龄匹配的孤立性输卵管性不孕症患者进行17个体外受精周期。观察到恶性疾病对卵母细胞的质量和行为有明显的不良影响。尽管两组每个周期的卵母细胞总数相当，但每个周期从恶性疾病患者那里获得的成熟卵母细胞比例显著降低。与对照组相比，恶性疾病患者的卵母细胞质量较差，受精率明显降低。我们认为，肿瘤过程，无论起源部位或细胞，都可能对卵母细胞的生物学产生有害影响，这种影响类似于某些恶性肿瘤患者的精子。
A case series of eight cycles of in-vitro fertilization (IVF) in five women diagnosed with malignant disorders is presented. These patients chose to defer definitive treatment for a chance for preservation of potential fertility. The response of these patients to ovarian stimulation, and the outcome, was compared,vith 17 IVF cycles in 12 age-matched patients with isolated tubal infertility. An apparent adverse influence of malignant disease on the quality and behaviour of oocytes was observed. Despite a comparable total number of oocytes per cycle in the two groups, a significantly reduced percentage of mature oocytes was retrieved per cycle from patients with malignant diseases. The oocytes from patients with malignant disorders were of a poorer quality and exhibited a significantly impaired fertilization rate compared to the controls. We propose that neoplastic processes, irrespective of the site or cell of origin, may have a detrimental impact on the biology of oocytes, an effect akin to that seen on spermatozoa in men with certain malignancies.