The Class I HDAC inhibitor RGFP963 enhances consolidation of cued fear extinction.
The Class I HDAC inhibitor RGFP963 enhances consolidation of cued fear extinction.
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DOI：
10.1101/lm.036699.114
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发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Ressler KJ
中科院分区：
文献类型：
--
作者：
Bowers ME;Xia B;Carreiro S;Ressler KJ
有证据表明，广泛的非特异性组蛋白脱乙酰酶（HDAC）抑制增强学习和记忆，然而，各种HDAC对特定形式的学习的贡献还不完全清楚。在这里，我们表明I类HDAC抑制剂RGFP 963增强了线索恐惧消退的巩固。然而，RGFP 966，HDAC 3的强抑制剂，并没有显着增强线索恐惧消退的巩固。这些数据扩展了先前的证据，证明I类HDAC在长期记忆的巩固中发挥作用，表明HDAC 1和/或HDAC 2，但不太可能是HDAC 3，可能作为消退保持的负调节因子。特异性HDAC抑制剂如RGFP 963的开发将进一步阐明特异性HDAC在各种类型的学习和记忆中的作用。此外，增强线索恐惧消退的HDAC抑制剂可能显示出治疗恐惧相关疾病的转化前景，包括创伤后应激障碍（PTSD）。
Evidence indicates that broad, nonspecific histone deacetylase (HDAC) inhibition enhances learning and memory, however, the contribution of the various HDACs to specific forms of learning is incompletely understood. Here, we show that the Class I HDAC inhibitor, RGFP963, enhances consolidation of cued fear extinction. However, RGFP966, a strong inhibitor of HDAC3, does not significantly enhance consolidation of cued fear extinction. These data extend previous evidence that demonstrate the Class I HDACs play a role in the consolidation of long-term memory, suggesting that HDAC1 and/or HDAC2, but less likely HDAC3, may function as negative regulators of extinction retention. The development of specific HDAC inhibitors, such as RGFP963, will further illuminate the role of specific HDACs in various types of learning and memory. Moreover, HDAC inhibitors that enhance cued fear extinction may show translational promise for the treatment of fear-related disorders, including post-traumatic stress disorder (PTSD).
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影响因子：
3.9
作者：
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通讯作者：
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影响因子：
7.6
作者：
Bowers, Mallory E.;Ressler, Kerry J.
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DOI：
10.1073/pnas.1213364110
发表时间：
2013-02-12
影响因子：
11.1
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