Genetic models of homosexuality: generating testable predictions
Genetic models of homosexuality: generating testable predictions
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DOI：
10.1098/rspb.2006.3684
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发表时间：
2006-12-22
影响因子：
4.7
通讯作者：
Rice, William R.
中科院分区：
文献类型：
--
作者：
Gavrilets, Sergey;Rice, William R.
同性恋在人类和其他物种中很常见，但人们对其遗传和进化基础知之甚少。在这里，我们制定和研究了一系列简单的数学模型，目的是预测经验模式，这些模式可以用来确定导致影响同性恋的基因多态的选择形式。具体地说，我们发展理论来对影响同性恋的基因的遗传特征进行对比预测，包括：(I)染色体位置，(Ii)分离等位基因之间的显性，以及(Iii)区分其多态的两种主要模式的效应大小：超显性模式和性拮抗模式。我们的结论是，在影响同性恋的基因的基因组筛查中发现的数量性状基因座(QTL)的遗传特征的测量，对于解决保持其多态的自然选择的形式具有很高的信息量。
Homosexuality is a common occurrence in humans and other species, yet its genetic and evolutionary basis is poorly understood. Here, we formulate and study a series of simple mathematical models for the purpose of predicting empirical patterns that can be used to determine the form of selection that leads to polymorphism of genes influencing homosexuality. Specifically, we develop theory to make contrasting predictions about the genetic characteristics of genes influencing homosexuality including: (i) chromosomal location, (ii) dominance among segregating alleles and (iii) effect sizes that distinguish between the two major models for their polymorphism: the overdominance and sexual antagonism models. We conclude that the measurement of the genetic characteristics of quantitative trait loci (QTLs) found in genomic screens for genes influencing homosexuality can be highly informative in resolving the form of natural selection maintaining their polymorphism.