THIOPENTAL EFFICACY IN PHENOBARBITAL-RESISTANT NEONATAL SEIZURES
THIOPENTAL EFFICACY IN PHENOBARBITAL-RESISTANT NEONATAL SEIZURES
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DOI：
10.1159/000457614
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发表时间：
1990-01-01
期刊：
影响因子：
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通讯作者：
DECAPITANI, E
中科院分区：
文献类型：
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作者：
BONATI, M;MARRARO, G;DECAPITANI, E
硫喷妥钠（10 mg/kg，i. v.）本文报告了9例重度窒息新生儿，在人工通气下，苯巴比妥抵抗新生儿癫痫发作的初步研究。癫痫发作的临床和脑电图控制迅速而坚决。未观察到对心血管功能（心率、血压）的不良影响。硫喷妥钠的终末半衰期平均为9小时，总血浆清除率为0.20 l/h/kg，稳态分布容积为3.6 l/h/kg。与苯巴比妥和苯妥英相比，本品在新生儿中的动力学特征表明其作用更快，持续时间更短。因此，从这些发现，硫喷妥钠可能提供一个有用的和方便的方法，苯巴比妥耐药的新生儿癫痫发作的安全和有效的治疗。
The successful treatment with thiopental (10 mg/kg, i.v.) of 9 severely asphyxiated newborns, under artifical ventilation, with neonatal seizures resistant to phenobarbital, is reported in this pilot study. The clinical and electroencephalogram control of seizures was prompt and resolute. No adverse effect on cardiovascular function (heart rate, blood pressure) was observed. The terminal half-life of thiopental averaged 9 h, the total plasma clearance 0.20 l/h/kg, and the steady-state volume of distribution 3.6 l/h/kg. The kinetic profile of the drug compared to phenobarbital and phenytoin in newborns suggests that its action is quicker and shorter lasting. Thus, from these findings, thiopental may offer a useful and handy approach for the safe and effective treatment of phenobarbital-resistant neonatal seizures.