Role of Descending Dopaminergic Pathways in Pain Modulation
Role of Descending Dopaminergic Pathways in Pain Modulation
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DOI：
10.2174/1570159x17666190430102531
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发表时间：
2019
影响因子：
5.3
通讯作者：
Tao Feng
中科院分区：
文献类型：
--
作者：
Li Changsheng;Liu Sufang;Lu Xihua;Tao Feng
Pain, especially when chronic, is a common reason patients seek medical care and it.affects the quality of life and well-being of the patients. Unfortunately, currently available therapies.for chronic pain are often inadequate because the neurobiological basis of such pain is still not fully.understood. Although dopamine has been known as a neurotransmitter to mediate reward and motivation,.accumulating evidence has shown that dopamine systems in the brain are also involved in.the central regulation of chronic pain. Most importantly, descending dopaminergic pathways play.an important role in pain modulation. In this review, we discuss dopamine receptors, dopaminergic.systems in the brain, and the role of descending dopaminergic pathways in the modulation of different.types of pain.
