Effect of polysialic acid on the behavior of retinal ganglion cell axons during growth into the optic tract and tectum.
Effect of polysialic acid on the behavior of retinal ganglion cell axons during growth into the optic tract and tectum.
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发表时间：
1995-10
期刊：
影响因子：
4.6
通讯作者：
X. Yin;M. Watanabe;U. Rutishauser
中科院分区：
文献类型：
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作者：
X. Yin;M. Watanabe;U. Rutishauser
我们以前已经证明，神经细胞黏附分子(NCAM)中的聚唾液酸(PSA)部分可以调节发育过程中的周围神经分支。特别是，人们发现，特定的酶从运动轴突中去除PSA会导致它们形成紧密的束状结构，对正常的指导提示反应较差。在本研究中，通过对鸡发育过程中视神经轴突的分析，研究了PSA在中枢神经系统轴突行为中的作用。与外周轴突不同，外周轴突通常在没有PSA的环境中生长，PSA被发现存在于视网膜神经节细胞轴突及其周围的束和顶盖中。此外，酶将PSA从视神经轴突中去除，导致视神经轴突在视束/顶盖区域脱束。这种反应在形态上类似于这些轴突在后来PSA水平下降时所做的靶向纠正，表明PSA可能用于保护它们不会过早地对其靶区的一些指导线索做出反应。
We have demonstrated previously that the polysialic acid (PSA) moiety of the neural cell adhesion molecule (NCAM) can regulate peripheral nerve branching during development. In particular, it was found that specific enzymatic removal of PSA from motor axons causes them to form tight fascicles that are less responsive to normal guidance cues. In the present study, the role of PSA in the behavior of axons in the central nervous system has been examined through an analysis of chick optic axons during development. Unlike peripheral axons, which generally grow in a PSA-free environment, PSA was found to be present both on retinal ganglion cell axons and their environment in the tract and tectum. Furthermore, the enzymatic removal of PSA from the optic axons caused them to defasciculate in the tract/tectal region. This response was morphologically similar to targeting corrections made by these axons at a later stage when PSA levels have decreased, suggesting that the PSA may serve to shield them from responding prematurely to some guidance cues in their target region.