Incidence trends in primary malignant penile cancer
Incidence trends in primary malignant penile cancer
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DOI：
10.1016/j.urolonc.2006.08.029
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发表时间：
2007-09-01
影响因子：
2.7
通讯作者：
Guiliano, Anna R.
中科院分区：
文献类型：
--
作者：
Barnholtz-Sloan, Jill S.;Maldonado, John L.;Guiliano, Anna R.
目的：检验。美国原发性恶性阴茎癌发病率的趋势方法和材料：1973年至2002年期间，从监测、流行病学和最终结果计划公共使用数据中诊断出的1，817名原发性恶性阴茎癌男性被用于分析。使用Surveillance，Epidemiology and End Results-Stat 6.1，通过感兴趣的临床和人口统计学变量以及诊断的十年（1973-1982，1983-1992和1993-2002）计算发病率，并使用年度百分比变化统计检查趋势。额外的发病率计算进行进一步的种族/民族difficulties.Results：从1973年至2002年，原发性恶性阴茎癌的总发病率为0.69每10万。发病率随时间显著下降：1973-1982年为每10万人0.84例，1982-1992年为每10万人0.69例，1993-2002年为每10万人0.58例。发病率随诊断时年龄的增加而增加。大多数病例为鳞状细胞癌，分级为I或11级，起源于阴茎头。在过去的30年中，级别不明的原发性恶性阴茎癌的发病率显著下降，原发部位阴茎（未另行说明的原发性恶性阴茎癌）的发病率也显著下降。区域性阶段疾病的发病率也随着时间的推移而增加。从1993年到2002年，白色西班牙裔的发病率最高（1.01每100，000），其次是阿拉斯加土著/美洲印第安人（0.77每100，000）和黑人（0.62每100，000）。结论：在美国的原发性恶性阴茎癌的总体发病率有所下降，这些比率因种族/民族而异。发病率随着诊断时年龄的增加而增加，区域性分期疾病的发病率随着时间的推移而增加，而在过去的30年中，级别不明的原发性恶性阴茎癌的发病率下降。(C)2007爱思唯尔公司All rights reserved.
Objective: To examine. trends in the incidence of primary, malignant penile cancer in the United States.Methods and materials: A total of 1,817 men with primary, malignant penile cancer diagnosed between 1973 and 2002 from the Surveillance, Epidemiology and End Results Program Public-use data were used for analysis. Incidence rates were calculated by clinical and demographic variables of interest and decade of diagnosis (1973-1982, 1983-1992, and 1993-2002) using Surveillance, Epidemiology and End Results-Stat 6.1, and trends were examined using the annual percent change statistic. Additional incidence calculations were performed to examine further racial/ethnic differences.Results: The overall incidence of primary, malignant penile cancer from 1973 to 2002 was 0.69 per 100,000. Incidence decreased significantly over time: 0.84 per 100,000 in 1973-1982 to 0.69 per 100,000 in 1982-1992 to 0.58 per 100,000 in 1993-2002. Incidence increased with increasing age at diagnosis. The majority of cases had squamous cell carcinomas, graded as I or 11, and originated at the glans penis. Incidence of unknown grade primary, malignant penile cancer decreased significantly over the last 30 years, as did incidence of primary site penis, not otherwise specified primary, malignant penile cancer. The incidence of regional stage disease also increased over time. From 1993 to 2002, White Hispanics had the highest incidence rates (1.01 per 100,000) followed by Alaska Native/American Indians (0.77 per 100,000) and Blacks (0.62 per 100,000).Conclusions: The overall incidence of primary, malignant penile cancer in the United States has decreased, and these rates varied by race/ethnicity. Incidence rates increased with increasing age at diagnosis, and the incidence of regional stage disease increased over time, while incidence of unknown grade primary, malignant penile cancer decreased over the last 30 years. (C) 2007 Elsevier Inc. All rights reserved.