Inhibitory reflexive effect of rectal distension on postprandial gastric myoelectrical activity
Inhibitory reflexive effect of rectal distension on postprandial gastric myoelectrical activity
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DOI：
10.1023/a:1020551824234
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发表时间：
2002-11-01
影响因子：
3.1
通讯作者：
Chen, JDZ
中科院分区：
文献类型：
--
作者：
Qian, L;Orr, WC;Chen, JDZ
本研究的目的是确定低容量直肠扩张对胃肌电活动的影响。该研究在14名健康志愿者中进行，分为2个随机阶段。在对照组中，将一个小气球插入肛门边缘10 cm外的直肠中，并充入20 ml空气。在空腹状态下和餐后30 min记录胃肌电活动;然后将球囊放气并取出，然后再记录30 min。研究阶段相同，但在30分钟基线记录后，球囊充盈至受试者感到排便紧迫的体积。进行频谱分析以计算胃慢波的主频、功率和规律性（2-4个周期/分钟，cpm）以及胃节律紊乱的百分比。结果：1）.与我们以前发表的数据相比，放置20毫升空气的直肠气囊并不影响慢波的规律性（空腹时84.2 +/- 3.6%，进食时85.3 +/- 4.3%）;与对照组相比，直肠扩张引起排便紧迫感（平均空气体积：72.5ml）显著降低了进食状态下胃慢波的规律性（72.0 +/-5.7%，P < 0.03 vs基线; P < 0.02 vs对照组），但在空腹状态下未发生（80.1 +/-4.5%，P = 0.1）。这种餐后变化归因于胃动过缓的显著增加（3.1 +/- 1.0% vs 7.9 +/-2.6%，P < 0.04）和胃动过速的轻微增加（7.4 +/- 2.5% vs 15.8 +/-4.3%，P = 0.06）。正常餐后增加的胃慢波的主频和功率被取消在这两个会议。结论：引起排便急迫感的直肠扩张会损害餐后胃慢波，使胃动过缓和胃动过速的百分比增加。
The aim of the study was to determine the effects of low-volume rectal distension on gastric myoelectrical activity. The study was performed in 14 healthy volunteers in 2 randomized sessions. In the control session, a small balloon was inserted into the rectum 10 cm beyond the anal verge and inflated with 20 ml of air. Gastric myoelectrical activity was recorded for 30 minutes in the fasting state and 30 minutes after a meal; and then the balloon was deflated and removed, and another 30-min recording was followed. The study session was the same except that after the 30-min baseline recording the balloon was inflated to reach a volume with which the subject felt an urgency for defecation. Spectral analyses were performed to compute the dominant frequency, power, and regularity (2-4 cycles/minutes, cpm) of the gastric slow waves and the percentage of gastric dysrhythmia. Results: 1). In comparison with our previously published data, the placement of the rectal balloon with a volume of 20 ml air did not affect the regularity of the slow waves (84.2 +/- 3.6% in fasting, 85.3 +/- 4.3% in fed); In comparison with the control session, the rectal distension inducing an urgency for defecation (average volume of air: 72.5 ml) significantly reduced the regularity of gastric slow waves in the fed state (72.0 +/- 5.7%, P < 0.03 vs baseline; P < 0.02, vs control session) but not in the fasting state (80.1 +/- 4.5%, P = 0.1). This postprandial change was attributed to a significant increase in bradygastria (3.1 +/- 1.0% vs 7.9 +/- 2.6%, P < 0.04) and a marginal increase in tachygastria (7.4 +/- 2.5% vs 15.8 +/- 4.3%, P = 0.06). The normal postprandial increases in the dominant frequency and power of the gastric slow wave were abolished in both sessions. conclusions, rectal distension evoking an urgency for defecation impairs postprandial gastric slow waves with an increase in the percentage of both bradygastria and tachygastria.