Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women.
Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women.
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DOI：
10.1016/j.ygeno.2019.07.008
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发表时间：
2019-07
期刊：
影响因子：
4.4
通讯作者：
J. Wong;Han Zhang;C. Hsiung;K. Shiraishi;Kai Yu;K. Matsuo;M. Wong;Yun-Chul Hong;Jiucun Wang;W. Seow;Zhaoming Wang;Minsun Song;H. Kim;I. Chang;N. Chatterjee;Wei Hu;Chen Wu;T. Mitsudomi;W. Zheng;J. H. Kim;A. Seow;N. Caporaso;M. Shin;L. Chung;S. An;Ping Wang;Yang Yang-Yang;Hong Zheng;Y. Yatabe;Xuchao Zhang;Y. T. Kim;Q. Cai;Zhihua Yin;Young-chul Kim;B. Bassig;Jiang Chang;J. Ho;B. Ji;Y. Daigo;Hidemi Ito;Y. Momozawa;K. Ashikawa;Y. Kamatani;T. Honda;H. Hosgood;H. Sakamoto;H. Kunitoh;K. Tsuta;Shun-ichi Watanabe;M. Kubo;Y. Miyagi;H. Nakayama;S. Matsumoto;M. Tsuboi;K. Goto;Jianxin Shi;L. Song;X. Hua;A. Takahashi;A. Goto;Y. Minamiya;K. Shimizu;Kazumi Tanaka;F. Wei;F. Matsuda;J. Su;Yeul-Hong Kim;I. Oh;F. Song;W. Su;Yu-Min Chen;G. Chang;Kuan-Yu Chen;Ming-Shyan Huang;L. Chien;Y. Xiang;J. Park;S. Kweon;Chien-Jen Chen;Kyoung-Mu Lee;Batel Blechter;Haixin Li;Yu-Tang Gao;B. Qian;D. Lu;Jianjun Liu;H. Jeon;C. Hsiao;J. Sung;Y. Tsai;Y. Jung;Huan Guo;Zhibin Hu;Wen-Chang Wang;Charles C. Chung;L. Burdett;M. Yeager;A. Hutchinson;S. Berndt;Wei Wu;H. Pang;Yuqing Li;J. Choi;K. Park;S. Sung;Li Liu;C. Kang;M. Zhu;Chung-Hsing Chen;Tsung-Ying Yang;Jun Xu;P. Guan;W. Tan;Chih-Liang Wang;M. Hsin;Ko-Yung Sit;J. Ho;Ying Chen;Y. Choi;J. Hung;Jun Suk Kim;H. Yoon;Chien-Chung Lin;I. Park;P. Xu;Yuzhuo Wang;Qincheng He;R. Perng;Chih-Yi Chen;R. Vermeulen;Junjie Wu;W. Lim;Kun-Chieh Chen;Yao-Jen Li;Jihua Li;Hongyan Chen;Chong-Jen Yu;Li Jin;Tzu-Yu Chen;S. Jiang;Jie Liu;T. Yamaji;B. Hicks;Kathleen Wyatt;Shengchao A Li;J. Dai;Hongxia Ma;G. Jin;B. Song;Zhehai Wang;Sensen Cheng;Xuelian Li;Yangwu Ren;P. Cui;M. Iwasaki;T. Shimazu;S. Tsugane;Junjie Zhu;Ying Chen;Kaiyun Yang;G. Jiang;K. Fei;Guoping Wu;Hsien-Chin Lin;Hui-Ling Chen;Yao-Huei Fang;Fang‐Yu Tsai;W. Hsieh;Jinming Yu;V. Stevens;I. Laird-Offringa;C. Marconett;Linda Rieswijk;A. Chao;Pan‐Chyr Yang;X. Shu;Tangchun Wu;Y. Wu;D. Lin;Kexin Chen;Baosen Zhou;Yunchao Huang;T. Kohno;Hongbing Shen;S. Chanock;N. Rothman;Q. Lan
中科院分区：
文献类型：
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作者：
J. Wong;Han Zhang;C. Hsiung;K. Shiraishi;Kai Yu;K. Matsuo;M. Wong;Yun-Chul Hong;Jiucun Wang;W. Seow;Zhaoming Wang;Minsun Song;H. Kim;I. Chang;N. Chatterjee;Wei Hu;Chen Wu;T. Mitsudomi;W. Zheng;J. H. Kim;A. Seow;N. Caporaso;M. Shin;L. Chung;S. An;Ping Wang;Yang Yang-Yang;Hong Zheng;Y. Yatabe;Xuchao Zhang;Y. T. Kim;Q. Cai;Zhihua Yin;Young-chul Kim;B. Bassig;Jiang Chang;J. Ho;B. Ji;Y. Daigo;Hidemi Ito;Y. Momozawa;K. Ashikawa;Y. Kamatani;T. Honda;H. Hosgood;H. Sakamoto;H. Kunitoh;K. Tsuta;Shun-ichi Watanabe;M. Kubo;Y. Miyagi;H. Nakayama;S. Matsumoto;M. Tsuboi;K. Goto;Jianxin Shi;L. Song;X. Hua;A. Takahashi;A. Goto;Y. Minamiya;K. Shimizu;Kazumi Tanaka;F. Wei;F. Matsuda;J. Su;Yeul-Hong Kim;I. Oh;F. Song;W. Su;Yu-Min Chen;G. Chang;Kuan-Yu Chen;Ming-Shyan Huang;L. Chien;Y. Xiang;J. Park;S. Kweon;Chien-Jen Chen;Kyoung-Mu Lee;Batel Blechter;Haixin Li;Yu-Tang Gao;B. Qian;D. Lu;Jianjun Liu;H. Jeon;C. Hsiao;J. Sung;Y. Tsai;Y. Jung;Huan Guo;Zhibin Hu;Wen-Chang Wang;Charles C. Chung;L. Burdett;M. Yeager;A. Hutchinson;S. Berndt;Wei Wu;H. Pang;Yuqing Li;J. Choi;K. Park;S. Sung;Li Liu;C. Kang;M. Zhu;Chung-Hsing Chen;Tsung-Ying Yang;Jun Xu;P. Guan;W. Tan;Chih-Liang Wang;M. Hsin;Ko-Yung Sit;J. Ho;Ying Chen;Y. Choi;J. Hung;Jun Suk Kim;H. Yoon;Chien-Chung Lin;I. Park;P. Xu;Yuzhuo Wang;Qincheng He;R. Perng;Chih-Yi Chen;R. Vermeulen;Junjie Wu;W. Lim;Kun-Chieh Chen;Yao-Jen Li;Jihua Li;Hongyan Chen;Chong-Jen Yu;Li Jin;Tzu-Yu Chen;S. Jiang;Jie Liu;T. Yamaji;B. Hicks;Kathleen Wyatt;Shengchao A Li;J. Dai;Hongxia Ma;G. Jin;B. Song;Zhehai Wang;Sensen Cheng;Xuelian Li;Yangwu Ren;P. Cui;M. Iwasaki;T. Shimazu;S. Tsugane;Junjie Zhu;Ying Chen;Kaiyun Yang;G. Jiang;K. Fei;Guoping Wu;Hsien-Chin Lin;Hui-Ling Chen;Yao-Huei Fang;Fang‐Yu Tsai;W. Hsieh;Jinming Yu;V. Stevens;I. Laird-Offringa;C. Marconett;Linda Rieswijk;A. Chao;Pan‐Chyr Yang;X. Shu;Tangchun Wu;Y. Wu;D. Lin;Kexin Chen;Baosen Zhou;Yunchao Huang;T. Kohno;Hongbing Shen;S. Chanock;N. Rothman;Q. Lan
我们使用亚洲女性肺癌联盟的结核病全基因组关联研究（GWAS）结果，调查了结核病（TB）的遗传易感性是否影响从不吸烟者肺腺癌的发生。采用自适应秩截尾乘积法进行通路分析，使用来自5512例肺腺癌病例和6277例对照的GWAS数据评估TB相关基因集与肺腺癌之间的关联。该基因集由31个基因组成，这些基因含有与来自先前TB-GWAS的遗传变异的已知/暗示关联。随后，我们采用孟德尔随机化方法进行随访，使用来自东亚人先前TB-GWAS的三个全基因组显著变异来评估TB与肺腺癌之间的关联。TB相关基因组与肺腺癌相关（p= 0.016）。此外，孟德尔随机化分析显示肺结核与肺腺癌相关（OR = 1.31，95%CI：1.03，1.66，p = 0.027）。我们的研究结果支持结核病是从不吸烟的亚洲女性肺癌发展的一个因果风险因素。
We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p= 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66,p= 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.