[A case of HTLV-1 associated myelopathy and adult T-cell leukemia, presenting unique muscle pathology including rimmed vacuole].
[A case of HTLV-1 associated myelopathy and adult T-cell leukemia, presenting unique muscle pathology including rimmed vacuole].
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[一例 HTLV-1 相关脊髓病和成人 T 细胞白血病，呈现独特的肌肉病理学，包括边缘空泡]。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
K. Tashiro
中科院分区：
文献类型：
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作者：
S. Honma;K. Yamada;F. Moriwaka;K. Shima;K. Tashiro
一名63岁的男性自1983年以来出现四肢肌肉萎缩和无力，并于1985年通过血清（x 2，500）和CSF（x 32）中HTLV-1抗体滴度升高被指出患有阴燃ATL。神经系统检查发现近端肌无力和四肢萎缩，双腿轻度痉挛。双臂深腱反射减退，双下肢腱反射亢进，伴踝阵挛，双侧Babinski反射和Chaddock反射阳性。这些发现与HAM一致。然而，他的步态明显蹒跚，需要支撑。左二头肌肌肉活检显示炎性改变，伴边缘空泡、小群萎缩和明显的1型纤维优势。这些肌肉活检的结果与以前报道的HAM病例不同，与包涵体肌炎或伴有边缘空泡的远端肌病有一些相似之处。
A 63-year-old man developed muscular atrophy and weakness in his four extremities since 1983, and was pointed out to have smoldering ATL by elevated HTLV-1 antibody titers in the serum (x 2,500) and CSF (x 32) in 1985. Neurological examinations revealed proximal muscular weakness and atrophy of four extremities, and mild spasticity of both legs. Deep tendon reflexes were hypoactive in both arms and hyperactive in both lower extremities with ankle clonus and bilateral positive Babinski and Chaddock reflexes. These findings were compatible with HAM. His gait, however, was markedly waddling, requiring support. Muscle biopsy at left biceps muscle revealed inflammatory change with rimmed vacuoles, small group atrophy, and marked type 1 fiber predominance. These findings on muscle biopsy are different from those of previously reported cases with HAM, showing some similarities to inclusion body myositis or distal myopathy with rimmed vacuole.