Orthostatic intolerance in chronic fatigue syndrome
Orthostatic intolerance in chronic fatigue syndrome
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DOI：
10.1186/s12967-019-1935-y
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发表时间：
2019-06-03
影响因子：
7.4
通讯作者：
Baraniuk, James N.
中科院分区：
文献类型：
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作者：
Garner, Richard;Baraniuk, James N.
研究背景立位不耐受（OI）是慢性疲劳综合征（CFS）患者的一个重要问题.我们的目的是在CFS的特点立位不耐受，并研究运动对OI.MethodsCFS（n=39）和对照组（n=25）的影响卧位和站立症状评估使用20点，锚定，有序的优雅盒量表之前和次极量运动后。心率的变化（HR 30 bpm）确定体位性心动过速综合征（POTS）运动前后，和短暂的，运动引起的体位性心动过速应激试验激活可逆性心动过速（START）表型只有后exercise. Results头晕和头晕被发现在41%的横卧CFS科目和72%的站立CFS科目。直立性心动过速不能解释CFS的OI症状。Gracely Box量表的ROC分析阈值为2/20，将CFS受试者分为三组：无OI（症状
BackgroundOrthostatic intolerance (OI) is a significant problem for those with chronic fatigue syndrome (CFS). We aimed to characterize orthostatic intolerance in CFS and to study the effects of exercise on OI.MethodsCFS (n=39) and control (n=25) subjects had recumbent and standing symptoms assessed using the 20-point, anchored, ordinal Gracely Box Scale before and after submaximal exercise. The change in heart rate (HR30bpm) identified Postural Orthostatic Tachycardia Syndrome (POTS) before and after exercise, and the transient, exercise-induced postural tachycardia Stress Test Activated Reversible Tachycardia (START) phenotype only after exercise.ResultsDizziness and lightheadedness were found in 41% of recumbent CFS subjects and in 72% of standing CFS subjects. Orthostatic tachycardia did not account for OI symptoms in CFS. ROC analysis with a threshold2/20 on the Gracely Box Scale stratified CFS subjects into three groups: No OI (symptoms