The effects of dietary selenium on the immune system in healthy men
The effects of dietary selenium on the immune system in healthy men
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DOI：
10.1385/bter:81:3:189
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发表时间：
2001-09-01
影响因子：
3.9
通讯作者：
Taylor, PC
中科院分区：
文献类型：
--
作者：
Hawkes, WC;Kelley, DS;Taylor, PC
11名男性连续120天食用天然含硒量高或低的食物。硒摄入量在21天内稳定在47微克/天，然后在99天内改为13微克/天或297微克/天，导致血液中硒和谷胱甘肽过氧化物酶浓度出现显著差异。血清免疫球蛋白、补体成分以及对流感疫苗的初次抗体反应没有变化。高硒组再次接种白喉疫苗后的抗体滴度高2.5倍。高硒组白细胞计数下降，低硒组白细胞计数上升，这主要是由粒细胞的变化引起的。高硒组细胞毒性T淋巴细胞和活化T细胞的明显增加仅接近统计学意义。高硒组在第45天淋巴细胞计数增加。在第45天，高硒组外周淋巴细胞在自身血清中对商陆有丝分裂原的体外增殖受到刺激，并在整个研究过程中保持升高，而低硒组的增殖直到第100天才增加。这项研究表明，硒在人体中的免疫增强特性至少部分是由于B淋巴细胞活化和增殖改善，可能还有T细胞功能增强的结果。
Eleven men were fed foods naturally high or low in selenium for 120 d. Selenium intake was stabilized at 47 mug/d for 21 d, then changed to either 13 or 297 mug/d for 99 d, leading to significantly different blood selenium and glutathione peroxidase concentrations. Serum immunoglobulins, complement components, and primary antibody responses to influenza vaccine were unchanged. Antibody titers against diphtheria vaccine were 2.5-fold greater after reinoculation in the high selenium group. White blood cell counts decreased in the high-selenium group and increased in the low-selenium group, resulting primarily from changes in granulocytes. Apparent increases in cytotoxic T-lymphocytes and activated T-cells in the high-selenium group only approached statistical significance. Lymphocyte counts increased on d 45 in the high-selenium group. In vitro proliferation of peripheral lymphocytes in autologous serum in response to pokeweed mitogen was stimulated in the high-selenium group by d 45 and remained elevated throughout the study, whereas proliferation in the low selenium group did not increase until d 100. This study indicates that the immune-enhancing properties of selenium in humans are the result, at least in part, of improved activation and proliferation of B-lymphocytes and perhaps enhanced T-cell function.