Early Response of SpecificIgEcan Predict Satisfaction with Sublingual Immunotherapy
Early Response of SpecificIgEcan Predict Satisfaction with Sublingual Immunotherapy
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DOI：
10.1002/lary.28762
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发表时间：
2020-06-20
期刊：
影响因子：
2.6
通讯作者：
Han, Doo Hee
中科院分区：
文献类型：
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作者：
Kim, Jin Youp;Rhee, Chae-Seo;Han, Doo Hee
目的 研究过敏性鼻炎患者屋尘螨舌下免疫治疗 (SLIT) 的基线和早期反应期间的预测参数。研究设计回顾性队列研究。方法 患者接受 SLIT 治疗至少 3 年，并在基线和 1 年随访时进行血清学检测，以研究预测参数。在 SLIT 3 年之前和之后评估 SLIT 的满意度、4 种鼻部症状和生活质量。 61 名患者入组，并根据 SLIT 3 年后的满意度分为两组：43 名患者满意（70.5%），18 名患者不满意（29.5%）。结果 满意组和不满意组之间的基线免疫学参数没有显着差异。然而，Dermatophagoides pteronyssinus (Dp)- 和 D. 都有变化。在 SLIT 早期反应期间，不满意组中的粉尘 (Df) 特异性 IgE 显着高于满意组（分别为 P= .006 和 P= .045）。结论 早期反应期间 Dp 和 Df 特异性 IgE 水平的变化可能是 SLIT 长期治疗结果良好的指标。这些结果表明，临床医生可以在 Dp 和 Df SLIT 后 1 年测量这些免疫学参数，以表明潜在的反应者与无反应者。证据水平 2b 喉镜，2020 年
Objective To investigate predictive parameters at baseline and during the early response to sublingual immunotherapy (SLIT) for house dust mites in allergic rhinitis patients. Study Design Retrospective cohort study. Methods Patients were treated with SLIT for at least 3 years and serological tests performed at baseline and at 1-year follow-up to investigate predictive parameters. Satisfaction with SLIT, 4 nasal symptoms, and quality of life were evaluated before and after 3 years of SLIT. Sixty-one patients were enrolled and divided into two groups depending on their satisfaction after 3 years of SLIT: 43 were satisfied (70.5%) and 18 were not (29.5%). Results Immunological parameters at baseline did not differ significantly between the satisfactory and unsatisfactory groups. However, changes in bothDermatophagoides pteronyssinus(Dp)- andD. farinae(Df)-specific IgEs were significantly higher in the unsatisfactory group than in the satisfactory group during the early response to SLIT (P= .006 andP= .045, respectively). Conclusion The changes in both Dp- and Df-specific IgE levels during early response may be indicators for favorable long-term treatment outcomes with SLIT. These results suggest that clinicians could measure these immunological parameters 1 year after Dp and Df SLIT to indicate potential responders versus nonresponders. Level of Evidence 2bLaryngoscope, 2020