Morphine induces conditioned place preference behavior in histidine decarboxylase knockout mice
Morphine induces conditioned place preference behavior in histidine decarboxylase knockout mice
复制标题
吗啡诱导组氨酸脱羧酶基因敲除小鼠的条件性位置偏好行为
DOI：
10.1016/j.neulet.2009.10.079
复制
发表时间：
2010-01-04
影响因子：
2.5
通讯作者：
Chen, Zhong
中科院分区：
文献类型：
--
作者：
Gong, Ying-xia;Zhang, Wei-ping;Chen, Zhong
药理学和损伤研究表明，组胺对吗啡诱导的奖赏寻求行为具有抑制作用。本研究采用组氨酸脱羧酶基因敲除（HDC-KO）小鼠进一步研究内源性组胺在吗啡诱导的奖赏寻求行为中的作用。条件性位置偏爱（CPP）存在于野生型（WT）和HDC-KO小鼠用5或10 mg/kg吗啡治疗。与WT小鼠相比，HDC-KO小鼠显示出更强的吗啡诱导的CPP。同时，吗啡显著增加VTA和NAc的多巴胺水平，尤其是在HDC-KO小鼠。然而，CPP的消退在WT和HDC-KO小鼠之间相似。此外，纳洛酮诱发的戒断跳跃在HDC-KO小鼠中显著减少。这些结果表明，内源性组胺抑制的发展，但不是灭绝，吗啡诱导的CPP和减少吗啡戒断症状，可能通过调节多巴胺能活性在大脑中。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Pharmacological and lesion studies have shown that histamine exerts inhibitory effects on morphine-induced reward-seeking behavior. The present study was designed to further investigate the involvement of endogenous histamine in morphine-induced reward-seeking behavior using histidine decarboxylase gene knockout (HDC-KO) mice. Conditioned place preference (CPP) was present in both wild-type (WT) and HDC-KO mice treated with 5 or 10 mg/kg morphine. HDC-KO mice showed stronger morphine-induced CPP as compared with WT mice. Meanwhile, morphine significantly increased dopamine level in the VTA and NAc, especially in HDC-KO mice. However, the extinction of CPP is similar between WT and HDC-KO mice. Moreover, naloxone-precipitated withdrawal jumping was markedly decreased in HDC-KO mice. These results indicate that endogenous histamine inhibits the development, but not the extinction, of morphine-induced CPP and reduces morphine withdrawal sign, probably through modulating dopaminergic activity in the brain. (C) 2009 Elsevier Ireland Ltd. All rights reserved.