Inflammatory bowel disease in Iceland, 1980-89. A retrospective nationwide epidemiologic study.
Inflammatory bowel disease in Iceland, 1980-89. A retrospective nationwide epidemiologic study.
复制标题
冰岛的炎症性肠病，1980-89 年。
DOI：
10.1080/00365529850166239
复制
发表时间：
1998
影响因子：
1.9
通讯作者：
E. Oddsson
中科院分区：
文献类型：
--
作者：
S. Björnsson;J. H. Jóhannsson;E. Oddsson
背景
1950 - 1979年在冰岛进行的一项全国性炎症性肠病（IBD）流行病学研究显示，发病率较低但稳步上升。调查了1980 - 89年冰岛IBD的发病率，并与邻国的报告进行了比较。
方法
通过审查提交给冰岛仅有的两个病理部门的所有小肠和大肠组织标本（具有任何类型的炎症），检索病例。还筛选了三家主要医院中所有提示克罗恩病（CD）的小肠X线记录。然后使用公认的确认或排除标准审查所有提示IBD病例的医院和门诊记录。
结果
溃疡性结肠炎（UC）的平均年发病率为11.7/100，000，CD为3.1/100，000。UC的最高年龄特异性发病率在30 - 39岁组中，CD在60 - 69岁组中。UC诊断时最常见的受累仅为直肠炎（54%）和CD结肠（54.7%）。
结论
这项研究表明，这两种疾病的发病率持续上升。与1970 - 1979年期间相比，UC的平均年发病率几乎增加了两倍，CD增加了三倍多，这两种情况下的统计学显著增加。
BACKGROUND
A previous nationwide epidemiologic study of inflammatory bowel disease (IBD) in Iceland in 1950-79 showed a low but steadily rising incidence. The incidence of IBD in Iceland in 1980-89 was investigated and compared with reports from neighboring countries.
METHODS
Cases were retrieved by a review of all small- and large-intestinal tissue specimens with any type of inflammation submitted to the only two departments of pathology in Iceland. All small-intestinal X-ray records suggestive of Crohn's disease (CD) in the three major hospitals were also screened. All hospital and outpatient records of cases suggestive of IBD were then reviewed using accepted criteria for confirmation or exclusion.
RESULTS
The mean annual incidence of ulcerative colitis (UC) was 11.7/100,000, and that of CD 3.1/100,000. The highest age-specific incidence of UC was in the group 30-39 years old and for CD in the group 60-69 years old. The most frequent involvement at diagnosis of UC was proctitis only, in 54%, and in CD colon only, in 54.7% of the patients.
CONCLUSIONS
This study shows a continuing increase in the incidence of both diseases. Compared with the period 1970-79, there has been an almost twofold increase in the mean annual incidence of UC and more than a threefold increase of CD, a statistically significant increase in both instances.