Corticospinal tract integrity is related to primary motor cortex thinning in relapsing-remitting multiple sclerosis
Corticospinal tract integrity is related to primary motor cortex thinning in relapsing-remitting multiple sclerosis
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DOI：
10.1177/1352458515576985
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发表时间：
2015-12-01
影响因子：
5.8
通讯作者：
Rovaris, Marco
中科院分区：
文献类型：
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作者：
Bergsland, Niels;Lagana, Maria Marcella;Rovaris, Marco
背景资料：复发-缓解型多发性硬化（RRMS）患者的白色损伤与皮质萎缩发展之间的关系尚不清楚。目的：探讨RRMS患者和健康对照者的皮质脊髓束完整性与初级运动皮质皮质形态测量之间的关系。51例RRMS患者和30例健康对照者接受了MRI检查，以进行皮质重建和皮质脊髓束完整性评估。偏相关和多元线性回归分析被用来调查局灶性和正常出现的白色物质（NAWM）损伤的皮质脊髓束的厚度和表面积的措施，初级运动皮质的协会。MRI测量和临床残疾之间的关系进行了评估，由扩展残疾状态量表和疾病持续时间也investigated.Results：在患者中，皮质厚度减少有关增加皮质脊髓束NAWM平均值，轴向和径向扩散率，除了皮质脊髓束病变体积。PMC厚度的最终多元线性回归模型仅保留NAWM轴向扩散率作为重要预测因子（调整后的R-2= 0.270，p= 0.001）。临床措施与NAWM皮质脊髓束integrity measurements.Conclusions：在RRMS的初级运动皮质变薄相关的改变，连接白色的问题，是最好的解释减少NAWM的完整性。
Background: The relationship between white matter injury and cortical atrophy development in relapsing-remitting multiple sclerosis (RRMS) remains unclear.Objectives: To investigate the associations between corticospinal tract integrity and cortical morphology measures of the primary motor cortex in RRMS patients and healthy controls.Methods: 51 RRMS patients and 30 healthy controls underwent MRI examination for cortical reconstruction and assessment of corticospinal tract integrity. Partial correlation and multiple linear regression analyses were used to investigate the associations of focal and normal appearing white matter (NAWM) injury of the corticospinal tract with thickness and surface area measures of the primary motor cortex. Relationships between MRI measures and clinical disability as assessed by the Expanded Disability Status Scale and disease duration were also investigated.Results: In patients only, decreased cortical thickness was related to increased corticospinal tract NAWM mean, axial and radial diffusivities in addition to corticospinal tract lesion volume. The final multiple linear regression model for PMC thickness retained only NAWM axial diffusivity as a significant predictor (adjusted R-2= 0.270, p= 0.001). Clinical measures were associated with NAWM corticospinal tract integrity measures.Conclusions: Primary motor cortex thinning in RRMS is related to alterations in connected white matter and is best explained by decreased NAWM integrity.