Cardio-Renal Anemia Syndrome
Cardio-Renal Anemia Syndrome
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DOI：
10.1159/000327342
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Anker, Stefan D.
中科院分区：
文献类型：
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作者：
von Haehling, Stephan;Anker, Stefan D.
心力衰竭（HF）是一种全身性疾病，也涉及心脏和血管系统以外的器官和组织。25%至50%的HE患者还受到一定程度的肾脏疾病的影响。贫血可能存在于HF患者中，特别是如果肾脏也受到影响。在约20%的非卧床HF患者中观察到贫血，但在晚期疾病或显著合并症患者中，其患病率可能增加至60%或更高。肾性贫血综合征（CRAS）是一种病理三角，其中主要衰竭器官是心脏或肾脏，一个器官的功能障碍导致另一个器官的功能障碍。仅在HE患者中存在贫血或肾脏疾病时死亡率增加。所有因HF住院的患者中约20%存在CRAS的完整临床表现。在这些患者中，观察到死亡率急剧增加。本文介绍了CRAS的分类系统，其临床意义和潜在的治疗途径。版权所有（C）2011 S. Karger AG，巴塞尔
Heart failure (HF) is a systemic disease that also involves organs and tissues other than the heart and the vasculature. Between 25 and 50% of patients with HE are also affected by some degree of kidney disease. Anemia may be present in patients with HF, particularly if the kidney is also affected. Anemia is observed in about 20% of patients with ambulatory HF, but its prevalence may increase to 60% or more in patients with advanced disease or significant co-morbidities. Cardio-renal anemia syndrome (CRAS) represents a pathological triangle in which the primary failing organ is either the heart or the kidney, and the dysfunction of one leads to dysfunction of the other. Mortality rates increase with only anemia or kidney disease being present in patients with HE The full clinical picture of CRAS is present in about 20% of all patients hospitalized for HF. In such patients, a steep increase in mortality rates has been observed. This article describes the suggested classification systems of CRAS, its clinical significance, and potential therapeutic avenues. Copyright (C) 2011 S. Karger AG, Basel