Fatal ECHO 24 infection in a patient with hypogammaglobulinemia: relationship to dermatomyositis-like syndrome.
Fatal ECHO 24 infection in a patient with hypogammaglobulinemia: relationship to dermatomyositis-like syndrome.
复制标题
低丙种球蛋白血症患者致命的 ECHO 24 感染：与皮肌炎样综合征的关系。
DOI：
10.1016/s0022-3476(77)80700-2
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
Alan D. Rogol
中科院分区：
文献类型：
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作者：
J. A. Bardelas;J. A. Bardelas;Jerry A. Winkelstein;Jerry A. Winkelstein;D.S.Y. Seto;D.S.Y. Seto;T. Tsai;T. Tsai;Alan D. Rogol;Alan D. Rogol
抗体介导免疫缺陷的患者可能会发展为罕见的“皮肌炎样”综合征，通常是进行性和致命的。我们观察到一名患有低丙种球蛋白血症的儿童，其皮肌炎样综合征与致死性、播散性ECHO 24感染相关。这种关联表明，在某些免疫缺陷患者中，致死性皮肌炎样综合征是受损宿主中病毒感染的表现。使用具有高滴度ECHO 24中和活性的母体血浆未能成功阻止感染进展。
Patients with deficient antibody-mediated immunity may develop a rare “dermatomyositis-like” syndrome, which is usually progressive and fatal. We have observed a child with hypogammaglobulinemia in whom a dermatomyositis-like syndrome was associated with a fatal, disseminated ECHO 24 infection. This association suggests that in some immunodeficient patients the fatal dermatomyositis-like syndrome is a manifestation of a viral infection in a compromised host. The use of maternal plasma, with a high titer of ECHO 24 neutralizing activity, was unsuccessful in arresting the progress of the infection.