Novel observations with FDOPA-PET imaging after early nigrostriatal damage.
Novel observations with FDOPA-PET imaging after early nigrostriatal damage.
复制标题
早期黑质纹状体损伤后 FDOPA-PET 成像的新观察。
DOI：
10.1002/mds.1168
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Barrio,JR
中科院分区：
文献类型：
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作者：
Yee,RE;Irwin,I;Milonas,C;Stout,DB;Huang,SC;Shoghi-Jadid,K;Satyamurthy,N;Delanney,LE;Togasaki,DM;Farahani,KF;Delfani,K;Janson,AM;Phelps,ME;Langston,JW;Barrio,JR
在1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）处理的松鼠猴中，通过正电子发射断层扫描（PET）测量纹状体6-[18 F]氟-L-多巴（FDOPA）动力学速率常数。扫描后，多巴胺能神经元的体视学计数在黑质，多巴胺（DA）和代谢产物的浓度测定在尾状核，壳核，黑质。分级剂量的MPTP产生多巴胺能神经元轻度至中度减少（10-35%）的动物，其中细胞损失的百分比与给予的MPTP的量成比例。纹状体DA和代谢物浓度相对不变的动物给予1.0和1.5毫克/公斤的MPTP，但2.0毫克/公斤的MPTP后显着降低。所有注射单剂量MPTP的动物均未显示明显的帕金森症体征。相比之下，所有MPTP给药动物的黑质中DA和代谢产物浓度均显著降低。黑质多巴胺能指数的减少并不平行减少纹状体，表明不同的敏感性黑质纹状体通路的MPTP的神经毒性作用。MPTP后FDOPA摄取（Ki）和脱羧（k3）的百分比变化与纹状体DA水平呈显著正相关，但与多巴胺能神经元数量无关。这表明FDOPA是纹状体DA水平的良好指标。© 2001运动障碍协会。
Striatal 6‐[18F]fluoro‐L‐DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐treated squirrel monkeys. After scanning, stereological counts of dopaminergic neurons were done in substantia nigra, and dopamine (DA) and metabolite concentrations were determined in the caudate, putamen, and substantia nigra. Graded doses of MPTP produced animals with mild to moderate reductions (10–35%) in dopaminergic neurons, where the percent of cell loss was proportional to the amount of MPTP given. Striatal DA and metabolite concentrations were relatively unchanged in animals given 1.0 and 1.5 mg/kg of MPTP, but were significantly reduced after 2.0 mg/kg of MPTP. All animals injected with a single dose of MPTP showed no overt signs of parkinsonism. In contrast, DA and metabolite concentrations in the substantia nigra were significantly reduced for all MPTP‐treated animals. Reduction of dopaminergic indices in the substantia nigra did not parallel reductions in the striatum, indicating differential sensitivity of the nigrostriatal pathway to the neurotoxic effects of MPTP. The percent change in FDOPA uptake (Ki) and decarboyxlation (k3) after MPTP showed significant positive correlations to striatal DA levels, but not to the number of dopaminergic neurons. This suggests that FDOPA is a good index of striatal DA levels. © 2001 Movement Disorder Society.