T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications.
T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications.
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DOI：
10.3390/ijerph182111094
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发表时间：
2021-10-21
影响因子：
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通讯作者：
Purohit S
中科院分区：
文献类型：
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作者：
Tran PMH;Kim E;Tran LKH;Khaled BS;Hopkins D;Gardiner M;Bryant J;Bernard R;Morgan J;Bode B;Reed JC;She JX;Purohit S
通过改变危险因素，可以减少1型糖尿病患者并发症的发生。我们对1646例确诊为1型糖尿病(T1D)的患者进行了横断面队列研究，建立了糖尿病周围神经病变(DPN)、自主神经病变(AN)、视网膜病变(DR)和肾病(DN)的临床风险评分。其中DPN 199例(12.1%)，AN 63例(3.8%)，DR 244例(14.9%)，糖尿病肾病88例(5.4%)。我们选择了五个变量包括在四个微血管并发症风险模型中：年龄，T1D诊断年龄，T1D持续时间，以及过去三次临床就诊中的平均收缩压和糖化血红蛋白。这些变量之所以被选中，是因为文献中有强有力的证据表明它们与糖尿病并发症有关，而且它们是可改变的危险因素。经乐观校正的R2和Harrell‘s C统计量分别为0.39和0.87，0.24和0.86，0.49和0.91，0.22和0.83。该工具旨在帮助患者了解他们目前的微血管并发症风险，并激励患者控制他们的HbA1c和收缩压，以降低他们发生这些并发症的风险。
Development of complications in type 1 diabetes patients can be reduced by modifying risk factors. We used a cross-sectional cohort of 1646 patients diagnosed with type 1 diabetes (T1D) to develop a clinical risk score for diabetic peripheral neuropathy (DPN), autonomic neuropathy (AN), retinopathy (DR), and nephropathy (DN). Of these patients, 199 (12.1%) had DPN, 63 (3.8%) had AN, 244 (14.9%) had DR, and 88 (5.4%) had DN. We selected five variables to include in each of the four microvascular complications risk models: age, age of T1D diagnosis, duration of T1D, and average systolic blood pressure and HbA1C over the last three clinic visits. These variables were selected for their strong evidence of association with diabetic complications in the literature and because they are modifiable risk factors. We found the optimism-corrected R2 and Harrell’s C statistic were 0.39 and 0.87 for DPN, 0.24 and 0.86 for AN, 0.49 and 0.91 for DR, and 0.22 and 0.83 for DN, respectively. This tool was built to help inform patients of their current risk of microvascular complications and to motivate patients to control their HbA1c and systolic blood pressure in order to reduce their risk of these complications.
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影响因子：
16.2
作者：
Nishimura, R;LaPorte, RE;Orchard, TJ
通讯作者：
Orchard, TJ
影响因子：
3.2
作者：
Ponirakis, Georgios;Petropoulos, Ioannis N.;Malik, Rayaz A.
通讯作者：
Malik, Rayaz A.
影响因子：
44.5
作者：
Huxley, Rachel R.;Peters, Sanne A. E.;Woodward, Mark
通讯作者：
Woodward, Mark
影响因子：
3.8
作者：
Kazemi, Maryam;Moghimbeigi, Abbas;Faradmal, Javad
通讯作者：
Faradmal, Javad
影响因子：
16.2
作者：
通讯作者：
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