Validation of candidate genes associated with cardiovascular risk factors in psychiatric patients.
Validation of candidate genes associated with cardiovascular risk factors in psychiatric patients.
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DOI：
10.1016/j.pnpbp.2011.08.001
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发表时间：
2012-03-30
影响因子：
5.6
通讯作者：
Ruaño G
中科院分区：
文献类型：
--
作者：
Windemuth A;de Leon J;Goethe JW;Schwartz HI;Woolley S;Susce M;Kocherla M;Bogaard K;Holford TR;Seip RL;Ruaño G
The purpose of this study was to identify genetic variants predictive of cardiovascular risk factors in a psychiatric population treated with second generation antipsychotics (SGA). 924 patients undergoing treatment for severe mental illness at four US hospitals were genotyped at 1.2 million single nucleotide polymorphisms. Patients were assessed for fasting serum lipid (low density lipoprotein cholesterol [LDLc], high density lipoprotein cholesterol [HDLc], and triglycerides) and obesity phenotypes (body mass index, BMI). Thirteen candidate genes from previous studies of the same phenotypes in non-psychiatric populations were tested for association. We confirmed 8 of the 13 candidate genes at the 95% confidence level. An increased genetic effect size was observed for triglycerides in the psychiatric population compared to that in the cardiovascular population.
