Differentiation of vascular tumors from vascular malformations by expression of Wilms tumor 1 gene: Evaluation of 126 cases
Differentiation of vascular tumors from vascular malformations by expression of Wilms tumor 1 gene: Evaluation of 126 cases
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DOI：
10.1016/j.jaad.2009.12.017
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发表时间：
2010-12-01
影响因子：
13.8
通讯作者：
Kokta, Victor
中科院分区：
文献类型：
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作者：
Al Dhaybi, Rola;Powell, Julie;Kokta, Victor
背景血管肿瘤和畸形的诊断可能具有挑战性，虽然它们最初可能看起来非常相似，但它们具有不同的临床过程和治疗。Wilms 肿瘤 1 (WT1) 基因表达已在许多不同的肿瘤中报告，包括血液系统恶性肿瘤和一些实体瘤。目的我们试图评估 WT1 在 126 个血管病变（64 个血管肿瘤、1 个 Masson 肿瘤和 61 个血管肿瘤）中的表达。 方法根据国际血管异常研究学会对血管异常的分类，研究了婴儿血管瘤、先天性血管瘤（非消退型、快速消退型、未特指）、化脓性肉芽肿、簇状血管瘤、樱桃状血管瘤、卡波西血管瘤等血管瘤中WT1的表达情况。 肉瘤和血管肉瘤。我们还研究了由血管角化瘤/疣状血管瘤、复合血管畸形、静脉畸形、球静脉畸形、淋巴管畸形/淋巴管瘤、毛细血管扩张和靶样含铁血黄素血管瘤组成的血管畸形中WT1的表达。 内皮免疫染色，而只有 3 例血管畸形为 WT1 阳性。此外，这些血管畸形中 WT1 的阳性是局灶性的，仅涉及血栓内的再内皮化新生血管。局限性恶性血管肿瘤的数量较少是一个限制。结论 WT1 的免疫组织化学检测可能是血管常规评估的有用工具 异常可以区分血管肿瘤和增殖与血管畸形。 WT1 染色可在疑难病例中为临床医生提供指导，因为阳性结果表明存在增殖性血管病变，而阴性结果可能表明存在血管畸形。
BackgroundVascular tumors and malformations can be challenging to diagnose Although they may initially appear very similar, they have distinct clinical courses and management Wilms tumor 1 (WT1) gene expression has been reported in many different tumors including hematologic malignancies and some solid tumors.ObjectiveWe sought to evaluate the expression of WT1 in 126 vascular lesions (64 vascular tumors, one Masson tumor, and 61 vascular malformations).MethodsBased on the International Society for the Study of Vascular Anomalies classification of vascular anomalies, we studied the expression of WT1 in vascular tumors composed of infantile hemangioma, congenital hemangiomas (non-involuting, rapidly involuting, and not otherwise specified) pyogenic granuloma, tufted angioma cherry angioma Kaposi sarcoma, and angiosarcoma. We also studied WT1 expression in vascular malformations composed of angiokeratoma/verrucous hemangioma, combined vascular malformations, venous malformations, glomuvenous malformations, lymphatic malformations/lymphangioma, telangiectasia, and targetoid hemosiderotic hemangioma.ResultsAll vascular tumors and proliferations had positive WT1 cytoplasmic endothelial immunostaining whereas only 3 vascular malformations were WT1 positive Moreover the positivity of WT1 in these vascular malformations was focal and involved only re-endothelialized neovessels within thrombi.LimitationsThe low number of malignant vascular tumors is a limitation.ConclusionsImmunohistochemical detection of WT1 could be a useful tool to routine evaluation of vascular anomalies allowing the distinction of vascular tumors and proliferations from vascular malformations. Staining for WT1 may guide the clinician in difficult cases, as positive results would suggest a proliferative vascular lesion whereas negative results might point to a vascular malformation.