Are physical measures related to patient-centred outcomes in ARDS survivors?
Are physical measures related to patient-centred outcomes in ARDS survivors?
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DOI：
10.1136/thoraxjnl-2016-209400
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发表时间：
2017-10
期刊：
影响因子：
10
通讯作者：
Needham DM
中科院分区：
文献类型：
--
作者：
Chan KS;Aronson Friedman L;Dinglas VD;Hough CL;Shanholtz C;Ely EW;Morris PE;Mendez-Tellez PA;Jackson JC;Hopkins RO;Needham DM
为 ARDS 12 个月内 ARDS 幸存者研究的物理测量选择提供信息 对参加美国多中心前瞻性研究（ARDSNet 长期结果研究 [ALTOS]，N=134）或马里兰州巴尔的摩多地点前瞻性研究（改善急性肺损伤患者的护理 [ICAP]，N=99）的 6 个月幸存者的数据进行二次分析。 6 个月随访时评估的身体指标根据世界卫生组织的国际残疾与健康分类进行分类：身体功能和结构、活动和参与。在 6 个月和 12 个月时评估以患者为中心的结果：生存率、住院治疗、在家存活状况以及与健康相关的生活质量。使用皮尔逊相关、线性和逻辑回归模型来量化身体测量与以患者为中心的结果之间的关联。在多变量回归中，没有任何 6 个月的身体功能和结构测量结果与 6 或 12 个月的结果显示出一致的关联。 6 分钟步行测试（一种活动测量）与 6 个月的 SF-36 身体成分评分相关（PCS，β 范围：0.99 至 1.52，p<0.05）。参与测量（功能表现清单，FPI；工具性日常生活活动，IADL）与 SF-36 PCS（β 范围：FPI，1.51 至 1.52；IADL，-1.88 至 -1.32；所有 p<0.05）和 Euro-QoL-5D 效用评分（β 范围：FPI，2.00 至 3.67；IADL， -2.89 至 -2.50；所有 p<0.01）在 6 个月和 12 个月时。在 6 个月的幸存者中，参与测量比 ARDS 12 个月内身体功能和结构的测量更好地反映了患者的生活质量，因此建议将其作为核心测量纳入未来的研究中。
To inform selection of physical measures for studies of ARDS survivors within 12 months of ARDS Secondary analysis of data from 6-month survivors participating in a U.S. multicenter prospective study (ARDSNet Long-Term Outcome Study [ALTOS], N=134) or a multi-site prospective study in Baltimore, MD (Improving Care of Acute Lung Injury Patients [ICAP], N=99). Physical measures, assessed at 6-month follow-up, were categorized according to the World Health Organization’s International Classification of Disability and Health: body functions and structures, activity, and participation. Patient-centered outcomes were evaluated at 6 and 12-months: survival, hospitalization, alive at home status, and health-related quality of life. Pearson correlation, linear and logistic regression models were used to quantify associations of physical measures with patient-centered outcomes. No 6-month body functions and structures measure demonstrated consistent association with 6- or 12-month outcomes in multivariable regression. The 6-minute walk test, an activity measure, was associated with 6-month SF-36 physical component scores (PCS, beta range: 0.99 to 1.52, p<0.05). Participation measures (Functional Performance Inventory, FPI; Instrumental Activities of Daily Living, IADLs) were associated with SF-36 PCS (beta range: FPI, 1.51 to 1.52; IADL, −1.88 to −1.32; all p<0.05) and Euro-QoL-5D utility score (beta range: FPI, 2.00 to 3.67; IADL, −2.89 to −2.50; all p<0.01) at 6- and 12-months. Participation measures better reflect patient quality-of-life than measures of body functions and structures within 12 months of ARDS among 6-month survivors, and are recommended for inclusion as a core measure in future studies.
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影响因子：
8.8
作者：
Fan E;Dowdy DW;Colantuoni E;Mendez-Tellez PA;Sevransky JE;Shanholtz C;Himmelfarb CR;Desai SV;Ciesla N;Herridge MS;Pronovost PJ;Needham DM
通讯作者：
Needham DM
DOI：
10.1164/rccm.201401-0158oc
发表时间：
2014-05-15
影响因子：
24.7
作者：
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通讯作者：
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影响因子：
38.9
作者：
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影响因子：
158.5
作者：
Herridge, Margaret S.;Tansey, Catherine M.;Cheung, Angela M.
通讯作者：
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影响因子：
24.3
作者：
Kon, Samantha S. C.;Canavan, Jane L.;Man, William D-C.
通讯作者：
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