Age- and sex-related effects on the neuroanatomy of healthy elderly
Age- and sex-related effects on the neuroanatomy of healthy elderly
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DOI：
10.1016/j.neuroimage.2005.02.042
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发表时间：
2005-07-01
期刊：
影响因子：
5.7
通讯作者：
Mazoyer, B
中科院分区：
文献类型：
--
作者：
Lemaître, H;Crivello, F;Mazoyer, B
年龄和性别的影响，以及它们之间的相互作用对健康老年人的脑结构解剖进行了评估，感谢一个队列的662名年龄从63岁到75岁的受试者的横断面研究。在每个受试者中采集T1和T2加权MRI扫描，并使用基于体素的方法进行进一步处理，该方法针对脑脊液（CSF）隔室的识别进行了优化。协方差分析显示了一个经典的神经解剖学性别二态性，男性表现出较大的灰质（GM），白色物质（WM），和CSF室体积，以及更大的WM和CSF分数，而女性表现出更大的GM分数。随着年龄的增长，GM和WM显著减少，而CSF体积显著增加。组织概率图分析表明，在这个年龄范围内，GM萎缩率最高的部位是初级皮质、角回和上级顶回、前额皮质的眶部和海马区。对于任何组织体积以及任何组织概率图，“性别”和“年龄”之间均无显著相互作用。这些研究结果表明，在生命的第七和第八个十年的脑萎缩是普遍存在的，并以不受“性别”调节的速度进行。(c)2005年爱思唯尔公司All rights reserved.
Effects of age and sex, and their interaction on the structural brain anatomy of healthy elderly were assessed thanks to a cross-sectional study of a cohort of 662 subjects aged from 63 to 75 years. T1- and T2-weighted MRI scans were acquired in each subject and further processed using a voxel-based approach that was optimized for the identification of the cerebrospinal fluid (CSF) compartment. Analysis of covariance revealed a classical neuroanatomy sexual dimorphism, men exhibiting larger gray matter (GM), white matter (WM), and CSF compartment volumes, together with larger WM and CSF fractions, whereas women showed larger GM fraction. GM and WM were found to significantly decrease with age, while CSF volume significantly increased. Tissue probability map analysis showed that the highest rates of GM atrophy in this age range were localized in primary cortices, the angular and superior parietal gyri, the orbital part of the prefrontal cortex, and in the hippocampal region. There was no significant interaction between "Sex" and "Age" for any of the tissue volumes, as well as for any of the tissue probability maps. These findings indicate that brain atrophy during the seventh and eighth decades of life is ubiquitous and proceeds at a rate that is not modulated by "Sex". (c) 2005 Elsevier Inc. All rights reserved.