Laser flare photometry and complications of chronic uveitis in children
Laser flare photometry and complications of chronic uveitis in children
复制标题
DOI：
10.1016/s0002-9394(03)00315-5
复制
发表时间：
2003-06-01
影响因子：
4.2
通讯作者：
Feuer, WJ
中科院分区：
文献类型：
--
作者：
Davis, JL;Dacanay, LM;Feuer, WJ
目的：探讨慢性葡萄膜炎儿童激光耀斑光度测定值、葡萄膜炎并发症和预后之间的可能关系。设计：回顾性图表回顾。方法：我们评估了16岁或以下的活动性、非感染性前膜炎、中间膜炎或全膜炎患者，并在两个学术机构之一进行了激光耀斑光度测定。将基线和随访期间列举的并发症与激光耀斑光度测定值和前房细胞计数进行比较。结果：59例患者（41例女孩，18例男孩，平均年龄10.3 +/- 3.5岁）可获得至少一个激光耀斑光度测定值（“耀斑”），定义为基线测量；其中38例患者在随访期间（中位11个月）至少进行了一次额外测量。基线时，35例患者（59%）出现葡萄膜炎并发症。基线时，激光耀斑光度值升高与并发症（任何并发症[P =.007]，后路联合[P =. 003]）呈正相关。随访期间并发症的发生与基线时并发症的存在相关（P = 0.018）。一组基线时低耀斑的患者在随访期间不论给予何种治疗均无并发症。结论：激光耀斑光度测定值与儿童葡萄膜炎并发症发生率呈正相关。激光耀斑光度法为监测儿童葡萄膜炎提供了一种新的方法。未来的研究将需要确定这些值是否具有预后重要性，以及最小化耀斑的治疗策略是否能减少葡萄膜并发症。(C) 2003年Elsevier Inc.版权所有。
PURPOSE: To investigate possible relationships between laser flare photometry values, complications of uveitis, and outcomes in children with chronic uveitis.DESIGN: Retrospective chart review.METHODS: We evaluated patients with active, noninfectious anterior, intermediate, or panuveitis who were 16 years of age or younger and who had laser flare photometry at one of two academic institutions. Complications enumerated at baseline and during follow-up were compared with laser flare photometry values and to anterior chamber cell counts.RESULTS: At least one laser flare photometry value ("flare"), defined as baseline measurement, was available for 59 patients (41 girls, 18 boys; mean age, 10.3 +/- 3.5 years); 38 of these patients had at least one additional measurement during follow-up (median 11 months). Complications of uveitis were present in 35 patients (59%) at baseline. There was a positive association between increased laser flare photometry values and complications at baseline (any complication [P =.007], posterior synechiae [P = .003]). The development of complications during follow-up was associated with the presence of complications at baseline (P =.018). A subgroup of patients with low flare at baseline had no complications during follow-up regardless of treatment given.CONCLUSIONS: There is a positive relationship between laser flare photometry values and the prevalence of complications of uveitis in children. Laser flare photometry provides a novel way to monitor children with uveitis. Future study will be needed to determine whether values have prognostic importance and whether a treatment strategy that minimizes flare results in fewer uveitic complications. (C) 2003 by Elsevier Inc. All rights reserved.