Ethnic Differences in Insulin Action in Obese African-American and Latino Adolescents
Ethnic Differences in Insulin Action in Obese African-American and Latino Adolescents
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DOI：
10.1210/jc.2010-0018
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发表时间：
2010-08-01
影响因子：
5.8
通讯作者：
Goran, Michael I.
中科院分区：
文献类型：
--
作者：
Hasson, Rebecca E.;Adam, Tanja C.;Goran, Michael I.
导言：尽管非洲裔儿童的胰岛素抵抗程度和身体成分相似，但与拉丁裔儿童相比，非洲裔儿童对静脉注射葡萄糖(AIR)的急性胰岛素反应更强。目前尚不清楚非裔美国人是否对口服葡萄糖挑战表现出夸大的胰岛素反应，以及在青春期晚期肥胖儿童中是否存在任何差异。目的：我们的目标是比较久坐不动的非裔肥胖非裔美国人(n=59)和拉丁裔青少年(n=83)口服葡萄糖耐量试验(OGTT)和静脉葡萄糖耐量试验(IVGTT)得出的葡萄糖和胰岛素指数。方法：在OGTT期间测量葡萄糖和胰岛素曲线下增量面积，并在IVGTT期间评估空气、胰岛素敏感性、倾向指数和葡萄糖有效性。结果：从OGTT来看，非裔美国人的血糖和胰岛素IAUC分别比拉丁裔青少年低29.1%和22.5%(P=0.01)。从IVGTT来看，非洲裔美国人的胰岛素敏感性和血糖有效性分别比拉丁裔低41.7%(P<；0.01)和50.0%(P=0.02)。非洲裔美国人的AIR(P=0.001)和倾向指数(P=0.02)分别比拉美裔高63.0%和48.8%。在控制了身体成分和脂肪分布后，这些发现仍然存在。结论：OGTT和IVGTT得出的血糖和胰岛素指数存在显著差异。根据IVGTT的测量，非洲裔美国人比拉丁裔青少年更具胰岛素抵抗。然而，在非裔美国青少年中，口服葡萄糖后并没有观察到对静脉注射葡萄糖反应的众所周知的高胰岛素血症。(临床内分泌代谢酶95：4048-4051,2010)
Introduction: African-American children have a greater acute insulin response to iv glucose (AIR) compared with Latino children despite a similar degree of insulin resistance and body composition. It is unclear whether African-Americans demonstrate an exaggerated insulin response to an oral glucose challenge and whether any differences are seen in more obese children in advanced pubertal development.Purpose: Our objective was to compare glucose and insulin indices derived from an oral glucose tolerance test (OGTT) and iv glucose tolerance test (IVGTT) in sedentary, obese African-American (n = 59) and Latino (n = 83) adolescents.Methods: Glucose and insulin incremental area under the curve was measured during an OGTT, and AIR, insulin sensitivity, disposition index, and glucose effectiveness were assessed during an IVGTT. Body composition was assessed via dual-energy x-ray absorptiometry and magnetic resonance imaging.Results: From the OGTT, glucose and insulin IAUC were 29.1 and 22.5% lower (P = 0.01) in African-Americans compared with Latino adolescents. From the IVGTT, insulin sensitivity and glucose effectiveness were 41.7% (P < 0.01) and 50.0% (P = 0.02) lower in African-Americans compared to Latinos. AIR (P = 0.001) and disposition index (P = 0.02) were 63.0 and 48.8% higher in African-Americans, respectively, compared with Latinos. These findings persisted after controlling for body composition and fat distribution.Conclusions: There were marked differences in glucose and insulin indices derived from the OGTT and IVGTT. African-Americans were more insulin resistant as measured by the IVGTT compared with the Latino adolescents. However, the well-described hyperinsulinemia in response to iv glucose was not observed after oral glucose in African-American adolescents. (J Clin Endocrinol Metab 95: 4048-4051, 2010)