Angiopoietins and angiopoietin-like proteins in angiogenesis
Angiopoietins and angiopoietin-like proteins in angiogenesis
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DOI：
10.1080/10623320600697989
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发表时间：
2006-03-01
影响因子：
--
通讯作者：
Oike, Yuichi
中科院分区：
文献类型：
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作者：
Morisada, Tohru;Kubota, Yoshiaki;Oike, Yuichi
血管网的形成需要多种内皮细胞生长因子。这些因素具有强大的血管生成作用，它们的精确协调对血管发育至关重要。其中，血管生成素通过Tie2受体发挥作用，其信号传导对调节血管稳定和重塑至关重要。据报道，血管生成素/Tie2信号参与内皮细胞的存活和迁移，调节血管重塑和维持血管完整性。最近的研究表明，血管生成素/Tie2信号也是淋巴管生成所必需的。作者和其他几个小组已经确定了六种血管生成素样蛋白（Angptls），它们含有一个卷曲的线圈结构域和一个纤维蛋白原样结构域，这两种结构域都是血管生成素的特征。有趣的是，尽管Angptls不结合血管生成素受体Tie2，但Angptls也通过调节内皮细胞的存活和迁移在血管生成中起作用。目前，Angptls是孤儿配体，但它们不仅对血管细胞有多效作用，而且对代谢和肿瘤生物学也有多效作用。本文综述了血管生成素和Angptls在血管生物学中的作用，并讨论了与这些因子和血管生成相关的分子机制。
Vascular network formation requires several endothelial cell growth factors. These factors have a potent angiogenic effect, and their precise coordination is essential for vascular development. Among them, angiopoietins function through the Tie2 receptor, whose signaling is critical to regulate vascular stabilization and remodeling. It has been reported that the angiopoietin/Tie2 signal is involved in survival and migration of endothelial cells and regulates vascular remodeling and maintenance of vascular integrity. More recent studies demonstrate that angiopoietin/Tie2 signaling is also required for lymphangiogenesis. The authors and several other groups have identified six angiopoietin-like proteins (Angptls) containing a coiled-coil domain and a fibrinogen-like domain, both of which are characteristic of angiopoietins. Interestingly, Angptls also function in angiogenesis through regulating survival and migration of endothelial cells, although Angptls do not bind the angiopoietin receptor Tie2. Currently, Angptls are orphan ligands, but they have been reported to have pleiotropic effects not only on vascular cells but also on metabolism and tumor biology. Here, the authors review current findings relating to the roles of angiopoietins and Angptls in vascular biology and discuss molecular mechanisms relevant to these factors and angiogenesis.