EARLY BREAKDOWN OF BLOOD-RETINAL BARRIER IN DIABETES
EARLY BREAKDOWN OF BLOOD-RETINAL BARRIER IN DIABETES
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DOI：
10.1136/bjo.59.11.649
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发表时间：
1975-01-01
影响因子：
4.1
通讯作者：
FIGO, GM
中科院分区：
文献类型：
--
作者：
CUNHAVAZ, J;FARIADEABREU, JR;FIGO, GM
血-视网膜屏障在视网膜病理生理过程中起着重要作用。用玻璃体荧光分光光度法研究血-视网膜屏障的临床新方法，具有定量、重复性好、灵敏度高等优点，符合临床要求。对一系列眼底看起来“正常”的糖尿病患者应用这种方法发现，在糖尿病视网膜受累的早期阶段，血-视网膜屏障存在显著的破坏。细分的程度可以衡量，以便进行比较和演变评估。通过玻璃体荧光分光光度法证实，血视网膜屏障的障碍在微动脉瘤或毛细血管闭塞可通过荧光素血管造影术证实之前就已出现。
The blood-retinal barrier plays an important part in the processes of retinal pathophysiology. A new clinical method for the study of the blood-retinal barrier by vitreous fluorophotometry appears to satisfy the necessary requirements in that it is quantitative and shows good reproducibility and high sensitivity. The application of this method to a series of diabetic patients with apparently "normal" fundi revealed the presence of a significant breakdown of the blood-retinal barrier in the early stages of retinal involvement in diabetes. The extent of the breakdown can be measured allowing for comparative and evolutionary evaluations. The disturbance of the blood-retinal barrier, as evidence by vitreous fluorophotometry, appears before microaneurysms or capillary closure can be demonstrated by fluorescein angiography.