Wall shear stress promotes intimal hyperplasia through the paracrine H2O2-mediated NOX-AKT-SVV axis
Wall shear stress promotes intimal hyperplasia through the paracrine H2O2-mediated NOX-AKT-SVV axis
复制标题
壁剪切应力通过旁分泌 H2O2 介导的 NOX-AKT-SVV 轴促进内膜增生
DOI：
10.1016/j.lfs.2018.05.045
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发表时间：
2018
期刊：
影响因子：
6.1
通讯作者：
Zhu Fangyu
中科院分区：
文献类型：
--
作者：
Zhang Haolong;Yang Zhipeng;Wang Jing;Wang Xuehu;Zhao Yu;Zhu Fangyu
AimsOscillatory wall shear stress（WSS）-linked oxidative stress promotes intimal hyperplasia（IH）development，but the underlying mechanisms are not completely understood.Materials and methodsWe used an in vivo rabbit carotid arterial stenosis model representing different levels of WSS and found that WSS was increased at 1 month with 50% stenosis and was accompanied by VSMCs proliferation and interstitial collagen accumulation.增加WSS可促进VSMC的NOX、AKT和生存素（SVV）的表达以及VSMC的增殖/迁移，并减少凋亡。我们的体外研究表明，H2 O2可促进培养的人脐静脉内皮细胞的增殖和迁移，同时抑制凋亡。从而加速IH的发展。
AimsOscillatory wall shear stress (WSS)-linked oxidative stress promotes intimal hyperplasia (IH) development, but the underlying mechanisms are not completely understood.Materials and methodsWe used an in vivo rabbit carotid arterial stenosis model representing different levels of WSS and found that WSS was increased at 1 month with 50% stenosis and was accompanied by VSMCs proliferation and interstitial collagen accumulation. Increased WSS promoted the expression of NOX, AKT, and survivin (SVV) and the proliferation/migration of VSMCs and reduced apoptosis.Key findingsOur in vitro study suggested that H2O2promoted proliferation and migration while suppressing apoptosis in cultured human umbilical vascular endothelial cells.SignificanceWe demonstrated that the elevation of WSS promotes VSMC proliferation and migration through the H2O2-mediated NOX-AKT-SVV axis, thereby accelerating IH development.