miRNA expression in pediatric failing human heart.
miRNA expression in pediatric failing human heart.
复制标题
DOI：
10.1016/j.yjmcc.2013.01.005
复制
发表时间：
2013-04
影响因子：
5
通讯作者：
Sucharov CC
中科院分区：
文献类型：
--
作者：
Stauffer BL;Russell G;Nunley K;Miyamoto SD;Sucharov CC
miRNAs是一种短的调控RNA，通过与靶mRNA的3'UTR相互作用来调控基因的表达。尽管人们已在成人和动物心脏病模型中广泛研究了miRNAs的作用，但对其在儿科心力衰竭患者中的表达却一无所知。与心力衰竭成人患者不同，儿科患者对磷酸二酯酶抑制剂（PDEi）治疗反应良好，这在门诊环境中是安全的，导致更少的心力衰竭急诊室就诊，更少的心脏病住院和改善NYHA分级。我们最近发现，小儿心力衰竭患者显示出与成人心力衰竭患者不同的独特分子谱。在这项研究中，我们首次表明，小儿心力衰竭患者显示出独特的miRNA谱，并且一些miRNA的表达与对PDEi治疗的反应相关。此外，我们表明，Smad4的表达，一个潜在的目标PDEi调节的miRNA，是正常的PDEi治疗的患者。由于miRNAs可用于治疗人类心力衰竭，我们的研究结果强调了定义儿童心力衰竭患者分子特征的重要性，因此可以为该人群设计适合年龄的治疗。
miRNAs are short regulatory RNAs that can regulate gene expression through interacting with the 3'UTR of target mRNAs. Although the role of miRNAs has been extensively studied in adult human and animal models of heart disease, nothing is known about their expression in pediatric heart failure patients. Different than adults with heart failure, pediatric patients respond well to phosphodiesterase inhibitor (PDEi) treatment, which is safe in the outpatient setting, results in fewer heart failure emergency department visits, fewer cardiac hospital admissions and improved NYHA classification. We have recently shown that the pediatric heart failure patients display a unique molecular profile that is different from adults with heart failure. In this study we show for the first time that pediatric heart failure patients display a unique miRNA profile, and that expression of some miRNAs correlate with response to PDEi treatment. Moreover, we show that expression of Smad4, a potential target for PDEi-regulated miRNAs, is normalized in PDEi-treated patients. Since miRNAs may be used as therapy for human heart failure, our results underscore the importance of defining the molecular characteristics of pediatric heart failure patients, so age-appropriate therapy can be designed for this population.
登录
查看更多内容
影响因子：
5.6
作者：
Heger, Jacqueline;Warga, Bjoern;Euler, Gerhild
通讯作者：
Euler, Gerhild
影响因子：
5
作者：
Sucharov, Carmen;Bristow, Michael R.;Port, J. David
通讯作者：
Port, J. David
影响因子：
120.7
作者：
Shaddy, Robert E.;Boucek, Mark M.;Tani, Lloyd Y.
通讯作者：
Tani, Lloyd Y.
影响因子：
3.4
作者：
Topkara, Veli K.;Mann, Douglas L.
通讯作者：
Mann, Douglas L.
影响因子：
4.8
作者：
Hauptman, Paul J.;Mikolajczak, Peter;Schnitzler, Mark A.
通讯作者：
Schnitzler, Mark A.