Central control of gastrointestinal motility.
Central control of gastrointestinal motility.
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胃肠道运动的中心控制。
DOI：
10.1097/med.0000000000000449
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Travagli RA
中科院分区：
文献类型：
--
作者：
Browning KN;Travagli RA
本文综述了控制上消化道的迷走神经回路的组织和结构，以及在生理和病理生理条件下迷走神经回路在胃运动调节中的作用的最新研究。调节胃功能的迷走神经回路是高度可塑性的，可以受到各种输入的调节，既有外周的，也有中枢的。最近在肥胖、发育、应激和神经紊乱领域的研究强调了中枢对这些脑干神经回路的输入在调节胃运动中的重要性。认识到中枢神经系统在调节、整合和调节胃运动中所起的关键作用，应该有助于促进对调节外周运动障碍的中枢机制的研究。
This review summarizes the organization and structure of vagal neurocircuits controlling the upper gastrointestinal tract, and more recent studies investigating their role in the regulation of gastric motility under physiological, as well as pathophysiological, conditions. Vagal neurocircuits regulating gastric functions are highly plastic, and open to modulation by a variety of inputs, both peripheral and central. Recent research in the fields of obesity, development, stress, and neurological disorders highlight the importance of central inputs onto these brainstem neurocircuits in the regulation of gastric motility. Recognition of the pivotal role that the central nervous system exerts in the regulation, integration, and modulation of gastric motility should serve to encourage research into central mechanisms regulating peripheral motility disorders.