Surface-engineered triboelectric nanogenerator patches with drug loading and electrical stimulation capabilities: Toward promoting infected wounds healing
Surface-engineered triboelectric nanogenerator patches with drug loading and electrical stimulation capabilities: Toward promoting infected wounds healing
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DOI：
10.1016/j.nanoen.2021.106004
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发表时间：
2021-03-22
期刊：
影响因子：
17.6
通讯作者：
Zhu, Jintao
中科院分区：
文献类型：
--
作者：
Du, Shuo;Zhou, Nuoya;Zhu, Jintao
皮肤伤口很常见，但由于细菌感染，其修复可能会受到严重影响。使用可穿戴摩擦纳米发电机（TENG）作为伤口部位的微型电刺激（ES）设备是修复感染皮肤伤口的一种有吸引力的策略。然而，开发集成 TENG 贴片以实现原位 ES 以及受控药物加载/释放仍然具有挑战性。在此，合理设计了柔性TENG贴片，其表面工程电极具有Mg-Al层状双氢氧化物作为智能药物容器和摩擦层，可加速感染伤口的愈合。表面工程 TENG 贴片表现出改进的摩擦发电性能和米诺环素的有效输送。体外结果表明，这种TENG贴片可以杀死几乎100%的大肠杆菌和金黄色葡萄球菌，并极大地促进成纤维细胞的增殖和迁移。将贴剂贴在小鼠全层皮肤缺损的金黄色葡萄球菌感染伤口上，可抑制伤口细菌（约96.7%）并促进皮肤组织修复过程，使感染伤口在10天内愈合。此外，还提出了一种新的交流低强度电场抗菌机制，该机制可归因于累积的电击穿效应和ES产生的H2O2破裂细菌膜。这项工作为感染伤口的治疗提供了一种便捷的解决方案，并为个性化医疗保健设备的微生物管理开辟了一条新途径。
Skin wounds are commonly seen, while their repair can be severely affected due to bacterial infections. Using the wearable triboelectric nanogenerators (TENGs) as miniaturized electrical stimulation (ES) devices at the wound site is an appealing strategy for infected skin wounds repair. However, the development of an integrated TENG patch to achieve in situ ES as well as controlled drug loading/release remains challenging. Herein, a flexible TENG patch is rationally designed with a surface-engineered electrode possessing Mg-Al layered double hydroxide as a smart drug container and friction layer to accelerate infected wounds healing. The surface engineered TENG patch exhibits improved triboelectricity-generation performance and effective delivery of minocycline. In vitro results show that such TENG patches can kill almost 100% of E. coli and S. aureus, and greatly promote the proliferation and migration of fibroblasts. Upon application to the S. aureus-infected wounds with full-thickness skin defect in mice, the patches can inhibit wound bacteria (similar to 96.7%) and facilitate the skin tissue repair process, allowing the infected wound to heal within 10 days. Moreover, a novel antibacterial mechanism of a low-intensity electric field from alternating current is proposed, which can be ascribed to the accumulated electrical breakdown effect and H2O2 produced by ES to rupture the bacterial membranes. This work offers a convenient solution for infected wound treatment and opens a new route for personalized healthcare devices for microbial management.