Towards a Better Vision of Retinoic Acid Signaling during Eye Development.
Towards a Better Vision of Retinoic Acid Signaling during Eye Development.
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DOI：
10.3390/cells11030322
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发表时间：
2022-01-19
期刊：
影响因子：
6
通讯作者：
Duester G
中科院分区：
文献类型：
--
作者：
Duester G
视黄酸(RA)通过调控视黄酸受体(RAR)的转录调节活性，对脊椎动物眼睛的发育起重要作用。在眼睛发育过程中，视泡和随后的视网膜产生维甲酸作为维生素A(视黄醇)的代谢物。视黄醇首先被视黄醇脱氢酶10(RDH10)转化为视黄醛，然后被所有三种视黄醛脱氢酶(ALDH1A1、ALDH1A2和ALDH1A3)转化为视黄醛。在早期的小鼠胚胎中，RA扩散到整个视盘、视泡和邻近的间充质中的组织，以刺激视泡的折叠形成视杯。视网膜随后产生的RA是视杯和周围视周间充质进一步形态发生所必需的；在这个阶段，RA的丧失会导致小眼炎和角膜及眼皮缺陷。RA通过与RA反应元件(RARs)上的核RARs结合来发挥作用，RARs可以激活或抑制关键基因的转录。RA与RARs的结合调节转录共调节因子的招募，如核受体辅活化子(NCOA)或核受体辅抑制子(NCoR)，后者反过来控制通用辅活化子p300或通用辅抑制子PRC2的结合。目前还没有基因被确定为眼睛发育过程中类风湿因子信号的直接靶点，因此未来的研究需要专注于识别这些基因及其稀有基因。旨在了解RA在体内如何正常控制眼睛发育的研究将为确定发育性眼睛缺陷的发生机制和改进治疗眼睛缺陷的策略提供有价值的基础知识。
Retinoic acid (RA) functions as an essential signal for development of the vertebrate eye by controlling the transcriptional regulatory activity of RA receptors (RARs). During eye development, the optic vesicles and later the retina generate RA as a metabolite of vitamin A (retinol). Retinol is first converted to retinaldehyde by retinol dehydrogenase 10 (RDH10) and then to RA by all three retinaldehyde dehydrogenases (ALDH1A1, ALDH1A2, and ALDH1A3). In early mouse embryos, RA diffuses to tissues throughout the optic placode, optic vesicle, and adjacent mesenchyme to stimulate folding of the optic vesicle to form the optic cup. RA later generated by the retina is needed for further morphogenesis of the optic cup and surrounding perioptic mesenchyme; loss of RA at this stage leads to microphthalmia and cornea plus eyelid defects. RA functions by binding to nuclear RARs at RA response elements (RAREs) that either activate or repress transcription of key genes. Binding of RA to RARs regulates recruitment of transcriptional coregulators such as nuclear receptor coactivator (NCOA) or nuclear receptor corepressor (NCOR), which in turn control binding of the generic coactivator p300 or the generic corepressor PRC2. No genes have been identified as direct targets of RA signaling during eye development, so future studies need to focus on identifying such genes and their RAREs. Studies designed to learn how RA normally controls eye development in vivo will provide basic knowledge valuable for determining how developmental eye defects occur and for improving strategies to treat eye defects.
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影响因子：
64.5
作者：
Lupiáñez DG;Kraft K;Heinrich V;Krawitz P;Brancati F;Klopocki E;Horn D;Kayserili H;Opitz JM;Laxova R;Santos-Simarro F;Gilbert-Dussardier B;Wittler L;Borschiwer M;Haas SA;Osterwalder M;Franke M;Timmermann B;Hecht J;Spielmann M;Visel A;Mundlos S
通讯作者：
Mundlos S
影响因子：
64.8
作者：
Germain, P;Iyer, J;Gronemeyer, H
通讯作者：
Gronemeyer, H
DOI：
10.1002/bdrb.21177
发表时间：
2016-06-01
影响因子：
--
作者：
Chawla, Bahaar;Schley, Elisa;Bohnsack, Brenda L.
通讯作者：
Bohnsack, Brenda L.
影响因子：
64.8
作者：
Dixon, Jesse R.;Selvaraj, Siddarth;Yue, Feng;Kim, Audrey;Li, Yan;Shen, Yin;Hu, Ming;Liu, Jun S.;Ren, Bing
通讯作者：
Ren, Bing
DOI：
10.1038/nrendo.2012.100
发表时间：
2012-10
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
通讯作者：
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