Probabilistic maps of the white matter tracts with known associated functions on the neonatal brain atlas: Application to evaluate longitudinal developmental trajectories in term-born and preterm-born infants.
Probabilistic maps of the white matter tracts with known associated functions on the neonatal brain atlas: Application to evaluate longitudinal developmental trajectories in term-born and preterm-born infants.
复制标题
白质图的概率图在新生儿脑图集上具有已知相关功能：评估纵向出生和早产儿的纵向发育轨迹的应用。
DOI：
10.1016/j.neuroimage.2015.12.026
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发表时间：
2016-03
期刊：
影响因子：
5.7
通讯作者：
Oishi K
中科院分区：
文献类型：
--
作者：
Akazawa K;Chang L;Yamakawa R;Hayama S;Buchthal S;Alicata D;Andres T;Castillo D;Oishi K;Skranes J;Ernst T;Oishi K
扩散张量成像（DTI）已广泛用于研究新生儿和婴儿大脑的发育，以及与早产等各种疾病或医疗状况相关的偏差。在这项研究中，我们创建了一个概率地图的纤维通路与已知的相关功能，在已发表的新生儿多模态图谱。感兴趣的路径包括表层白色物质（SWM）纤维下方的特定cytoarchitectonically定义的皮质区，这是难以评估与现有的DTI分析方法。应用Jülich细胞结构图谱来定义与特定脑功能相关的皮层区域，并应用动态规划（DP）方法来描绘穿过SWM的白色物质通路。通过描绘11名健康足月新生儿的这些结构，为与运动、躯体感觉、听觉、视觉和边缘系统功能以及主要白色物质束（如胼胝体、额枕下束和小脑中脚）相关的通路创建概率图。为了表征这些通路的扩散率测量中与成熟相关的变化，然后将概率图应用于49名健康婴儿的DTI，这些婴儿在三个时间点（大约间隔五周）进行纵向扫描。首先，我们调查了19名足月出生婴儿的正常发育模式。接下来，我们分析了30名早产儿，以确定与早产相关的发育模式。最后，我们研究了这些组之间的扩散措施的差异，以评估早产对这些功能通路的发展的影响。足月出生和早产儿都表现出时间依赖性的扩散率下降，表明出生后这些途径的成熟，与侧皮质脊髓束和视辐射。足月和早产儿之间的比较表明，早产儿比足月出生的婴儿在这些途径中的三个：胼胝体的身体;左下纵束;和连接左侧初级/次级视觉皮层和枕颞视觉皮层（V5/MT+）的运动敏感区的途径的扩散率。概率图提供了一个机会，调查每个白色物质途径的发展变化。白色物质通路的改变是否可以预测功能结果将在后续研究中进一步研究。
Diffusion tensor imaging (DTI) has been widely used to investigate the development of the neonatal and infant brain, and deviations related to various diseases or medical conditions like preterm birth. In this study, we created a probabilistic map of fiber pathways with known associated functions, on a published neonatal multimodal atlas. The pathways-of-interest include the superficial white matter (SWM) fibers just beneath the specific cytoarchitectonically defined cortical areas, which were difficult to evaluate with existing DTI analysis methods. The Jülich cytoarchitectonic atlas was applied to define cortical areas related to specific brain functions, and the Dynamic Programming (DP) method was applied to delineate the white matter pathways traversing through the SWM. Probabilistic maps were created for pathways related to motor, somatosensory, auditory, visual, and limbic functions, as well as major white matter tracts, such as the corpus callosum, the inferior fronto-occipital fasciculus, and the middle cerebellar peduncle, by delineating these structures in eleven healthy term-born neonates. In order to characterize maturation-related changes in diffusivity measures of these pathways, the probabilistic maps were then applied to DTIs of 49 healthy infants who were longitudinally scanned at three time-points, approximately five weeks apart. First, we investigated the normal developmental pattern based on 19 term-born infants. Next, we analyzed 30 preterm-born infants to identify developmental patterns related to preterm birth. Last, we investigated the difference in diffusion measures between these groups to evaluate the effects of preterm birth on the development of these functional pathways. Term-born and preterm-born infants both demonstrated a time-dependent decrease in diffusivity, indicating postnatal maturation in these pathways, with laterality seen in the corticospinal tract and the optic radiation. The comparison between term- and preterm-born infants indicated higher diffusivity in the preterm-born infants than in the term-born infants in three of these pathways: the body of the corpus callosum; the left inferior longitudinal fasciculus; and the pathway connecting the left primary/ secondary visual cortices and the motion-sensitive area in the occipitotemporal visual cortex (V5/MT+). Probabilistic maps provided an opportunity to investigate developmental changes of each white matter pathway. Whether alterations in white matter pathways can predict functional outcomes will be further investigated in a follow-up study.