Mitochondrial DNA repair and damage tolerance.
Mitochondrial DNA repair and damage tolerance.
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线粒体 DNA 修复和损伤耐受。
DOI：
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
E. Sia
中科院分区：
文献类型：
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作者：
Alexis Stein;E. Sia
线粒体DNA （mtDNA）的精确维护是真核细胞组装功能性电子传递链所必需的。这种独立维持的基因组依赖于导入线粒体的核编码蛋白来进行复制和修复过程。几十年的研究已经清楚地表明，线粒体采用强大而多样的mtDNA修复和损伤耐受机制，以确保线粒体基因组的适当维护。本文综述了我们目前对酵母和哺乳动物系统中mtDNA修复和损伤耐受途径的理解，包括碱基切除修复、错配修复、同源重组、非同源末端连接、翻译合成和mtDNA降解。
The accurate maintenance of mitochondrial DNA (mtDNA) is required in order for eukaryotic cells to assemble a functional electron transport chain. This independently-maintained genome relies on nuclear-encoded proteins that are imported into the mitochondria to carry out replication and repair processes. Decades of research has made clear that mitochondria employ robust and varied mtDNA repair and damage tolerance mechanisms in order to ensure the proper maintenance of the mitochondrial genome. This review focuses on our current understanding of mtDNA repair and damage tolerance pathways including base excision repair, mismatch repair, homologous recombination, non-homologous end joining, translesion synthesis and mtDNA degradation in both yeast and mammalian systems.