Relapsing polychondritis - pathogenic role of anti-native collagen type II antibodies. A case report with immunological and pathological studies.
Relapsing polychondritis - pathogenic role of anti-native collagen type II antibodies. A case report with immunological and pathological studies.
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复发性多软骨炎 - 抗天然 II 型胶原蛋白抗体的致病作用。
DOI：
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发表时间：
1981
影响因子：
3.9
通讯作者：
A. Ryckewaert
中科院分区：
文献类型：
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作者：
O. Meyer;J. Cyna;A. Dryll;C. Cywiner‐Golenzer;M. Wassef;A. Ryckewaert
报告1例复发性多发性肌炎合并干燥综合征。诊断证实耳软骨活检。患者血清中存在抗大鼠肋软骨抗体。使用被动血凝技术检测抗II型胶原抗体，其滴度与临床病程显著相关。直接免疫荧光使用患者的耳软骨作为目标，表明抗胶原抗体可能发挥主要的致病作用的过程中复发性多囊炎。
A patient with relapsing polychondritis and Sjogren's syndrome is reported. Diagnosis was confirmed by ear cartilage biopsy. Antibodies against rat costal cartilage were present in the patient's serum. Antinative collagen type II antibodies were detected using a passive hemagglutination technique and the titer grossly correlated with the clinical course. Direct immunofluorescence using the patient's ear cartilage as a target suggested that anti-collagen antibodies might play a major pathogenic role in the course of relapsing polychondritis.