The predicting value of postoperative body temperature on long-term survival in patients with rectal cancer
The predicting value of postoperative body temperature on long-term survival in patients with rectal cancer
复制标题
术后体温对直肠癌患者长期生存的预测价值
DOI：
10.1007/s13277-015-3535-7
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Wang, Jianping
中科院分区：
文献类型：
--
作者：
Luo, Shuangling;Chen, Wenhao;Yang, Zihuan;Wang, Jianping
本研究旨在评估直肠癌患者术后体温与预后之间的关系。本研究纳入了507例I至III期直肠癌患者。回顾性分析术后每日基础体温（BBT，在早上6点测量）和最高体温（MBT）。根据每天BBT和MBT的中位数将患者分为两组。主要终点为无病生存期（DFS）和总生存期（OS）。单因素和多因素分析显示，低D 0-MBT患者（<37.4 °C）的患者3年DFS较低[校正风险比（HR）1.56（95% CI 1.08- 2.24，P = 0.017）]以及OS [校正HR 1.72（95% CI 1.05- 2.82，P = 0.032）]率。在318例T3期肿瘤患者亚组和458例未输血患者亚组中，低D 0-MBT仍然是DFS/OS的独立预测因子，校正HR等于1.48（95%CI 1.02- 2.24，P = 0.046）/1.68（95%CI 1.04- 2.99，P = 0.048）和1.45（95%CI 1.02- 2.13，P = 0.048）/1.59（95%CI 1.01- 2.74，P = 0.049）。此外，我们发现，如果患者术前BBT较低（<36.6 °C），则1年复发的风险较高（17% vs. 10%，P= 0.034）。术后低体温（D 0-MBT < 37.4 °C）是直肠癌患者生存不良的独立预测因素。
This study aimed to assess the association between postoperative body temperature and prognosis in patients with rectal cancer. Five hundred and seven patients with stage I to III rectal cancers were enrolled in the current study. Basal body temperature (BBT, measured at 6 am) and maximal body temperature (MBT) on each day after surgery were analyzed retrospectively. Patients were divided into two equal groups according to the median of BBT and MBT at each day. The primary end points were disease-free survival (DFS) and overall survival (OS). The univariate and multivariate analyses showed that patients with low D0-MBT (<37.4 °C) had lower 3-year DFS [adjusted hazard ratio (HR) 1.56 (95 % CI 1.08–2.24,P= 0.017)] as well as OS [adjusted HR 1.72 (95 % CI 1.05–2.82,P= 0.032)] rate as compared to those with high D0-MBT (>37.4 °C). In the subset of 318 patients with T3 stage tumor and the subgroup of 458 patients without blood transfusion as well, low D0-MBT continues to be an independent predictor of DFS/OS with an adjusted HR equal to 1.48 (95 % CI 1.02–2.24,P= 0.046)/1.68 (95 % CI 1.04–2.99,P= 0.048) and 1.45 (95 % CI 1.02–2.13,P= 0.048)/1.59 (95 % CI 1.01–2.74,P= 0.049), respectively. In addition, we found that patients have higher risk of 1-year recurrence if those were exhibiting low preoperative BBT (<36.6 °C) (17 vs. 10 %,P= 0.034). Low body temperature (D0-MBT < 37.4 °C) after surgery was an independent predictor of poor survival outcomes in patients with rectal cancer.
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DOI：
10.1891/9780826121646.0002
发表时间：
2018-09
期刊：
Cancer Rehabilitation
影响因子：
--
作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
通讯作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
影响因子：
--
作者：
M. Kluger
通讯作者：
M. Kluger
影响因子：
3.9
作者：
Kalady, Matthew F.;DeJulius, Kathryn L.;Church, James M.
通讯作者：
Church, James M.
影响因子：
158.5
作者：
Sauer, R;Becker, H;Raab, R
通讯作者：
Raab, R
DOI：
10.1016/s0140-6736(82)90081-2
发表时间：
1982-11
期刊：
The Lancet
影响因子：
--
作者：
W. John;B. Hodgson;A. Lowenfels
通讯作者：
W. John;B. Hodgson;A. Lowenfels