Chlamydia trachomatis and Human Papillomavirus Infection in Women From Southern Hunan Province in China: A Large Observational Study
Chlamydia trachomatis and Human Papillomavirus Infection in Women From Southern Hunan Province in China: A Large Observational Study
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中国湖南省南部妇女沙眼衣原体和人乳头瘤病毒感染：一项大型观察性研究
DOI：
10.3389/fmicb.2020.00827
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发表时间：
2020-05-05
影响因子：
5.2
通讯作者：
Li, Zhongyu
中科院分区：
文献类型：
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作者：
Chen, Hongliang;Luo, Lipei;Li, Zhongyu
沙眼衣原体和人乳头瘤病毒（HPV）是性传播感染（STI）最常见的病原体，可增加宫颈癌和不孕的风险。本研究的目的是评估C.在中国湖南省南部参加年度体检、辅助生殖治疗和到妇科诊所就诊的妇女中检测沙眼和/或HPV感染。从5006名参与者中采集了宫颈拭子样本。我们发现C.沙眼、HPV感染和C.沙眼/HPV混合感染率分别为4.7%（236/5006）、15.5%（778/5006）和1.2%（59/5006），无症状感染率分别为3.8%（38/1006）、10.8%（109/1006）和0.6%（6/1006）。25.0%（59/236）的C.沙眼衣原体感染和7.6%（59/778）的HPV感染可归因于沙眼衣原体。沙眼和HPV混合感染。C.沙眼和HPV感染多见于25岁以下的年轻女性（分别为10.4%和21.3%）和妇科门诊患者（分别为5.2%和18.0%）。值得注意的是，C. HPV阳性者沙眼感染率（7.6%）高于HPV阴性者（4.2%），HPV阴性者沙眼感染率高于HPV阳性者（4.2%）。前三名C。沙眼衣原体E、F、J基因型分别占1.4%、1.1%、0.8%; HPV 52、16、58基因型分别占4.2%、2.3%、2.2%。在151例有阴道镜检查数据的门诊患者中，HPV感染与严重宫颈病变相关，OR为15.86（95%CI 3.14-80.0，P < 0.001），而C.沙眼感染与低级别阴道镜检查结果相关（OR = 3.25，95% CI：1.22-8.65，P = 0.018）。我们的数据强调了无症状C的高患病率。沙眼和HPV感染，特别是<25岁的女性。这两种病原体可能作为共同的危险因素，增加感染和宫颈病变的风险。HPV和C的广泛实施。沙眼筛查方案，特别是针对年轻妇女的方案，将是减轻性传播感染负担的有效战略。
Chlamydia trachomatis and human papillomavirus (HPV) are the most common pathogens of sexually transmitted infections (STIs), which can increase the risk of cervical cancer and infertility. The purpose of this study was to evaluate the prevalence, genotype and risk factors of C. trachomatis and/or HPV infection in women attending the annual physical examination, assistant reproductive treatment and visiting the gynecology clinics from Southern Hunan province in China. Cervical-swab samples were collected from 5006 participants. We found that the overall prevalence of C. trachomatis, HPV infection and C. trachomatis/HPV coinfection was 4.7% (236/5006), 15.5% (778/5006) and 1.2% (59/5006), while the prevalence of asymptomatic infection of that was 3.8% (38/1006), 10.8% (109/1006) and 0.6% (6/1006), respectively. Furthermore, 25.0% (59/236) of C. trachomatis infection and 7.6% (59/778) of HPV infection were attributable to C. trachomatis and HPV coinfection. C. trachomatis and HPV infection were more often observed in young women of less than 25 years (10.4% and 21.3%, respectively) and in the outpatients from gynecology clinics (5.2% and 18.0%, respectively). Of note, a higher prevalence of C. trachomatis infection was observed in HPV-positive women (7.6%) than HPV- negative ones (4.2%), and vice versa. The top three C. trachomatis genotypes were E (1.4%), F (1.1%) and J (0.8%), and the counterparts of HPV genotypes were HPV52 (4.2%), HPV16 (2.3%) and HPV58 (2.2%), respectively. Among the 151 outpatients with colposcopy data, HPV infection was associated with severe cervical lesions with OR of 15.86 (95% CI 3.14–80.0, P < 0.001) while C. trachomatis infection was more likely associated with a low grade colposcopy impression (OR = 3.25, 95% CI: 1.22–8.65, P = 0.018). Our data highlight the high prevalence of asymptomatic C. trachomatis and HPV infection, particularly among women of <25 years. The two pathogens may serve as mutual risk factors to increase the risk of infections and cervical lesions. Widespread implementation of HPV and C. trachomatis screening programs, especially for young women, would be an effective strategy to relieve the burden of sexually transmitted infections.