Location-probability profiles for the mouth region of human primary motor-sensory cortex: Model and validation
Location-probability profiles for the mouth region of human primary motor-sensory cortex: Model and validation
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DOI：
10.1006/nimg.2000.0659
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发表时间：
2001-01-01
期刊：
影响因子：
5.7
通讯作者：
Lancaster, JL
中科院分区：
文献类型：
--
作者：
Fox, PT;Huang, A;Lancaster, JL
人类初级运动皮层（M1）的月份表征不能通过表面解剖可靠地确定，但可以通过空间坐标可靠地定位。在本报告中，进行了三种定量元分析，共同描述了人类m1口表征的平均位置、位置变异性和位置概率分布。首先，对主体间功能区可变性进行文献荟萃分析，使用了11项针对每个主体的研究，每项研究都报告了一个或多个脑区域的主体间可变性的坐标参考测量。从这些数据中，计算出受试者间变异性的加权平均值，该值被证明很小（5.6 mm，标准差），跨坐标轴（x, y, z）一致，跨脑区域一致。其次，使用7个坐标参考的群体平均研究（共71名受试者）对m1口的位置进行文献荟萃分析，每个研究报告了mi口的大平均位置。由此，确定了加权平均位置和总变异性（实验室间和个体间）的加权值。以这两篇文献元分析作为输入数据，使用功能体建模（FVM）统计模型计算参考空间的基数轴（x、y和z）的位置概率分布。第三，对30名正常受试者的内部PET数据进行原始数据元分析。mi -mouth平均位置、位置变异性和位置概率分布与两篇文献元分析中FVM联合建模的结果一致。总的来说，这些观察结果提供了一个详细的、一致的概率描述人类m1嘴在标准化坐标中的位置。(C) 2001学术出版社。
The month representation of the human, primary motor cortex (M1) is not reliably identified by surface anatomy but may be reliably localized by means of spatial coordinates. For this report, three quantitative metanalyses were performed which jointly described the mean location, location variability and location-probability profiles of the human M1-mouth representation. First, a literature metanalysis of intersubject functional-area variability was performed using eleven, per-subject studies, each of which reported a coordinate-referenced measure of intersubject variability for one or more brain areas. From these data, a weighted-mean value for intersubject variability was computed, which proved to be small (5.6 mm, standard deviation), consistent across coordinate axes (x, y, z), and consistent across brain areas. Second, a literature metanalysis of the location of M1-mouth was performed using seven, coordinate-referenced, group-mean studies (71 subjects in all), each of which reported a grand-average location for MI-mouth. From this, a weighted-mean location and weighted values for total variability (interlaboratory plus interindividual) were determined. Using these two literature metanalyses as input data, location-probability profiles were computed for the cardinal axes (x, y, and z) of the reference space, using the functional volumes modeling (FVM) statistical model. Third, an original-data metanalysis was performed on in-house PET data from 30 normal subjects performing overt-speech tasks. MI-mouths mean location, location variability, and location-probability profiles were consistent with those conjointly modeled by FVM from the two literature metanalyses. Collectively, these observations provide a detailed, consensus probabilistic description of the location of the human M1-mouth representation in standardized coordinates. (C) 2001 Academic Press.