REACTION OF THE SUBSTANTIA NIGRA TO MASSIVE BASAL GANGLIA INFARCTION
REACTION OF THE SUBSTANTIA NIGRA TO MASSIVE BASAL GANGLIA INFARCTION
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DOI：
10.1007/bf00684925
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发表时间：
1983-01-01
影响因子：
12.7
通讯作者：
FORNO, LS
中科院分区：
文献类型：
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作者：
FORNO, LS
人类黑质可以通过几种方式对基底神经节的破坏做出反应。在10例单侧基底节大面积梗死患者中，同侧黑质出现轻度至中度神经细胞丢失。在大多数年幼的实验动物中没有观察到严重的神经细胞损失。1例在同侧黑质内可见有髓和无髓纤维构成的网状结构，包围着着色神经细胞和树突。本例黑质的电镜研究显示神经丝增生，成对的螺旋丝和罕见的直丝，但仅在纹状体梗死的同侧。10例中的神经细胞丢失被解释为主要是逆行变性，例10中的神经元周芽是对部分传入神经阻滞的反应，成对的螺旋丝是基底节破坏同侧黑质中的逆行或跨突触反应。
The human substantia nigra can react to destruction of the basal ganglia in several ways. In 10 brains with massive unilateral infarction of the basal ganglia slight to moderate nerve cell loss was present in the ipsilateral substantia nigra. The severe nerve cell loss reported in mostly young experimental animals was not observed. One case also displayed a fine network of myelinated and unmyelinated fibers surrounding pigmented nerve cells and dendrites in the ipsilateral substantia nigra. EM studies of the substantia nigra from this case showed neurofilamentous hyperplasia, paired helical filaments and rare straight filaments, but only on the side ipsilateral to the striatal infarct. The nerve cell loss in the 10 cases was interpreted as a mainly retrograde degeneration, the perineuronal sprouts in case 10 as a reaction to partial deafferentation, and the paired helical filaments as either a retrograde or a transsynaptic reaction in the substantia nigra ipsilateral to the basal ganglia destruction.