WHOLE-BODY VASCULAR REACTIVITY DURING DEVELOPMENT OF DEOXYCORTICOSTERONE ACETATE HYPERTENSION IN PIG
WHOLE-BODY VASCULAR REACTIVITY DURING DEVELOPMENT OF DEOXYCORTICOSTERONE ACETATE HYPERTENSION IN PIG
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DOI：
10.1161/01.res.42.6.764
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发表时间：
1978-01-01
影响因子：
20.1
通讯作者：
BOHR, DF
中科院分区：
文献类型：
--
作者：
BERECEK, KH;BOHR, DF
在醋酸脱氧皮质酮（DOCA）高血压的发展过程中，猪的血管反应性发生了变化。对8-12周龄的猪进行单侧肾切除术，并在升主动脉上安装电磁流量探针，在主动脉和胸腔静脉中安装Tygon导管。手术后约2周，皮下植入DOCA（100 mg/kg）浸渍的硅橡胶条。在植入后的前3天内，平均动脉压（MAP）开始上升，并在第4周达到比对照组高约40%的水平。在发生高血压之前和期间，对未麻醉的猪进行分级静脉输注去甲肾上腺素或血管紧张素II。通过记录MAP和心输出量计算总外周阻力的变化。DOCA前反应曲线与DOCA植入后间隔时间获得的反应曲线的比较表明，DOCA后血管平滑肌对两种药物的敏感性显著增加（阈值输注速率降低）。剂量-反应曲线也向左移动。全身血管反应性的这些变化发生在动脉压开始升高时。时间关系表明，血管反应性的增加可能会引发平均动脉压的增加。
A change in vascular reactivity was characterized in the pig during the development of deoxycorticosterone acetate (DOCA) hypertension. Pigs, 8-12 wk of age, were subjected to unilateral nephrectomy and instrumented with an electromagnetic flowprobe on the ascending aorta and with Tygon catheters in the aorta and thoracic vena cava. Approximately 2 wk after surgery, Silastic strips impregnated with DOCA (100 mg/kg) were implanted s.c. Within the first 3 days after implantation, mean arterial pressure (MAP) began to rise and reached levels approximately 40% greater than control during the 4th wk. Graded i.v. infusions of norepinephrine or angiotensin II were given to unanesthetized pigs before, and at intervals during, the development of hypertension. Changes in total peripheral resistance were calculated from recordings of MAP and cardiac output. Comparison of pre-DOCA response curves with those obtained at intervals following DOCA implantation demonstrated a significant increase in vascular smooth muscle sensitivity (decrease in threshold infusion rates) to both drugs post-DOCA. There also was a shift to the left in the dose-response curves. These changes in systemic vascular reactivity occurred at the time the arterial pressure began to rise. The temporal relationship suggests that the increase in vascular reactivity may initiate the increase in mean arterial pressure.