Neural substrates of cue reactivity: association with treatment outcomes and relapse.
Neural substrates of cue reactivity: association with treatment outcomes and relapse.
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DOI：
10.1111/adb.12314
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发表时间：
2016-01
影响因子：
3.4
通讯作者：
Ray LA
中科院分区：
文献类型：
--
作者：
Courtney KE;Schacht JP;Hutchison K;Roche DJ;Ray LA
鉴于有强有力的证据表明药物依赖引起的神经系统改变，功能磁共振成像(FMRI)是成瘾临床神经科学中的重要工具。FMRI线索-反应范式是探索成瘾中奖赏/动机系统的神经生物学通路参与的理想平台，并潜在地提供了一种翻译机制，可以用来测试干预和行为预测。因此，本文综述了将fMRI线索-反应范式应用于成人物质使用障碍治疗反应研究的研究进展。利用fMRI线索反应范式预测复发，并作为一种手段来调查心理社会和药物治疗对线索诱导的脑激活的影响的研究，主要包括四类物质：酒精、尼古丁、可卡因和阿片类药物。最后，对如何利用功能磁共振成像技术促进成瘾科学和治疗的发展提出了建议。
Given the strong evidence for neurological alterations at the basis of drug dependence, functional magnetic resonance imaging (fMRI) represents an important tool in the clinical neuroscience of addiction. fMRI cue-reactivity paradigms represent an ideal platform to probe the involvement of neurobiological pathways subserving the reward/motivation system in addiction and potentially offer a translational mechanism by which interventions and behavioral predictions can be tested. Thus, this review summarizes the research that has applied fMRI cue-reactivity paradigms to the study of adult substance use disorder treatment responses. Studies utilizing fMRI cue-reactivity paradigms for the prediction of relapse, and as a means to investigate psychosocial and pharmacological treatment effects on cue-elicited brain activation are presented within four primary categories of substances: alcohol, nicotine, cocaine, and opioids. Lastly, suggestions for how to leverage fMRI technology to advance addiction science and treatment development are provided.