Interfering with theories of sleep and memory: Sleep, declarative memory, and associative interference
Interfering with theories of sleep and memory: Sleep, declarative memory, and associative interference
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DOI：
10.1016/j.cub.2006.05.024
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发表时间：
2006-07-11
期刊：
影响因子：
9.2
通讯作者：
Thompson-Schill, Sharon L.
中科院分区：
文献类型：
--
作者：
Ellenbogen, Jeffrey M.;Hulbert, Justin C.;Thompson-Schill, Sharon L.
越来越多的人类行为证据支持这样的说法，即睡眠有助于改善最近获得的非陈述性记忆。例子包括运动序列学习[1，2]；视觉辨别学习[3]；以及合成语言的知觉学习[4]。相比之下，有有限的人类数据支持睡眠对人类的陈述性(海马体介导的)记忆的好处(有关综述，请参阅[5])。考虑到动物模型(例如，[6-8])和神经成像研究(例如，[9])预测睡眠有助于基于海马体的记忆巩固，这尤其令人惊讶。我们假设，我们可以通过用竞争信息(干扰)挑战陈述性记忆系统来揭示睡眠的好处。这是第一项证明睡眠保护陈述性记忆不受后续联想干扰的研究，它对理解记忆巩固的神经生物学具有重要意义。
Mounting behavioral evidence in humans supports the claim that sleep leads to improvements in recently acquired, nondeclarative memories. Examples include motor-sequence learning [1, 2]; visual-discrimination learning [3]; and perceptual learning of a synthetic language [4]. In contrast, there are limited human data supporting a benefit of sleep for declarative (hippocampus-mediated) memory in humans (for review, see [5]). This is particularly surprising given that animal models (e.g., [6-8]) and neuroimaging studies (e.g., [9]) predict that sleep facilitates hippocampus-based memory consolidation. We hypothesized that we could unmask the benefits of sleep by challenging the declarative memory system with competing information (interference). This is the first study to demonstrate that sleep protects declarative memories from subsequent associative interference, and it has important implications for understanding the neurobiology of memory consolidation.